微胶囊化技术与方法

A. Kakimov, A. Mayorov, G. Zhumadilova, A. Muratbayev, M. M. Tashybaeva
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引用次数: 0

摘要

本文综述了微胶囊技术和方法在现代制药和食品工业中的应用。卫生保健最重要的任务之一是向人民提供安全、有效、高质量和负担得起的药品。对哈萨克斯坦医药市场上国产药品主要发展速度的分析仍然具有现实意义。分析了微胶囊的物理、化学、理化形式。借助微胶囊技术,可以解决以下任务:降低药品的反应性,延长不稳定和易腐药品的保质期,降低物质的毒性,赋予物质新的物理性质,减少挥发性,改变密度,隐藏色、味、味。微胶囊可以确保药物的长期效果。微胶囊化实现:保护不稳定药物不受环境影响(维生素、抗生素、酶、疫苗、血清等);藏着苦药的味道;在胃肠道所需部位分离药物(肠溶性微胶囊);获得高质量的胶囊,其性质和特征在所需的环境中溶解,保留治疗效果,同时满足消费者的要求(易用性,效率,合理的成本)的问题仍然是开放的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MICROCAPSULATION – TECHNOLOGIES AND METHODS
The article presents an overview of the application of technologies and methods of microcapsules in modern pharmaceuticals and the food industry. One of the most important tasks of healthcare is to provide the population with safe, effective, high-quality and affordable medicines. The analysis of the main rates of development of domestic medicines in the pharmaceutical market of Kazakhstan remains relevant. Microcapsulation is analyzed for physical, chemical, physico-chemical forms. With the help of microcapsulation, the following tasks can be solved: to reduce the reactivity of medicines, extend the shelf life of unstable and perishable medicines, reduce the toxicity of the substance, give the substance new physical properties, reduce volatility, change density, hide color, taste, smell. Microcapsules make it possible to ensure the long-term effect of medicines. Microcapsulation achieves: protection of unstable drugs from environmental influences (vitamins, antibiotics, enzymes, vaccines, serums, etc.); hiding the taste of bitter medicines; isolation of medicines in the desired part of the gastrointestinal tract (intestinalsoluble microcapsules); the question of obtaining high-quality capsules with properties and characteristics that dissolve in the desired environment, retain the therapeutic effect and at the same time meet the requirements of the consumer (ease of use, efficiency, reasonable cost) is still open.
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