经椎间孔硬膜外阻滞治疗椎间盘突出和神经根性疼痛的疗效分析

A. Krivoshapkin, I. D. Savitskiy, A. Gushcha, V. Klimov, G. S. Sergeyev, I. A. Savitskaya, A. S. Gaitan, O. Abdullaev
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引用次数: 0

摘要

目标。目的:探讨经椎间孔硬膜外阻滞(TEB)治疗椎间盘突出症的疗效和安全性,并将其与其他方法治疗的效果进行比较。材料和方法。对248例有手术指征的腰椎间盘突出伴持续性神经根痛综合征患者的治疗结果进行了分析。70例患者行TEB治疗,若疗效不佳(疼痛严重程度减轻不到50%),则建议手术干预。178例手术治疗-显微手术或内镜下椎间盘切除术。采用VAS、Oswestry问卷和肢体运动功能障碍MRC量表对患者进行为期2年的随访。1个月后,TEB组神经根疼痛强度下降50%或以上,频率(84.3%)低于手术治疗组(93.8%),差异无统计学意义(p = 0.526)。同时,在不需要手术治疗的情况下,62.9%的TEB组患者实现了神经根疼痛的稳定减少(50%或更多)。两组间局部腰痛VAS评分(p = 0.179)和ODI评分(p = 0.348)差异无统计学意义。24个月后,与手术治疗组相比,TEB组功能结局的益处得到了中位ODI (4 [0;8] vs . 12 [4;20])和中位VAS对腰痛的评价(0 [0;1] vs 1 [0;3]), p < 0.001。TEB组所有患者的神经根痛VAS评分均显著下降(50%或以上),而手术治疗组为88.8% (p < 0.05)。在TEB组中,42例(60.0%)患者在没有后续手术干预的情况下获得了稳定的镇痛效果,并且由于各种原因进行重复手术干预的次数明显减少(p = 0.001),需要重复手术治疗的手术患者的椎间盘突出复发发生率相当(p > 0.05)。经椎间孔硬膜外阻滞(TEB)用于治疗腰椎间盘突出和持续性神经根疼痛的患者,使62.9%的患者在短期内可以避免手术治疗,60.0%的患者在术后两年随访期间可以避免手术治疗,同时保持高质量的生活。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The use of transforaminal epidural block in patients with herniated discs and radicular pain
Objective. To  study the efficacy and safety of transforaminal epidural block (TEB) in patients with herniated intervertebral discs, as well as to compare the results of their treatment with those achieved in patients who were treated with other methods.Material and Methods. The results of treatment of 248 patients with herniated intervertebral discs and persistent radicular pain syndrome, who had indications for surgical treatment, were studied. In 70 cases, the TEB was performed, and in case of its low efficacy (less than 50 % reduction in pain severity), surgical intervention was suggested. In 178 cases, surgical treatment was performed – microsurgical or endoscopic discectomy. The state of patients was followed-up during two years using VAS, Oswestry questionnaire and MRC scale for motor dysfunction in the limb.Results. After 1 month, a decrease in the intensity of radicular pain (by 50 % or more) was determined in the TEB group with a lower frequency (84.3 %) than in the surgical treatment group (93.8 %), without a statistically significant difference (p = 0.526). At the same time, a stable reduction in radicular pain (by 50 % or more) without the need for surgical treatment was achieved in 62.9 % of patients in the TEB group. Also, there was not significant difference in VAS score for local low back pain (p = 0.179) and ODI score (p = 0.348) between groups. After 24 months, the benefits of functional outcomes in the TEB group as compared with the surgical treatment group were confirmed by median ODI (4 [0; 8] vs 12 [4; 20], respectively)  and median VAS for low back pain (0 [0; 1] vs 1 [0; 3], respectively), p < 0.001. A significant (50 % or more) decrease in VAS score for radicular pain was achieved in all patients of the TEB group, while in the surgical treatment group – in 88.8 % (p > 0.05). In the TEB group, a stable analgesic effect without subsequent surgical intervention was achieved in 42 (60.0 %) patients, and the  number of repeated surgical interventions performed for various reasons was significantly  lower (p = 0.001), with a comparable incidence of disc herniation recurrence among operated patients who required repeated surgical treatment (p > 0.05).Conclusion. The use of transforaminal epidural block (TEB) in the treatment of patients with herniated intervertebral discs at the lumbar level and persistent radicular pain makes it possible to avoid surgical treatment in 62.9 % of patients in the short term, and in 60.0 % during two year follow-up after the procedure, while maintaining a high quality of life.
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