Nonlinear CMOS Image Sensor with SOC Integrated Local Contrast Stretch for Bio-Microfluidic Imaging

A nonlinear single-slope ADC with SOC integrated local contrast stretch using a configurable multi-frequency counter for bio-microfluidic imaging is presented in this paper. Compared with the conventional off-chip global contrast stretching algorithm, this method does not degrade image quality at the interested light intensity range (cell) at the cost of unconsidered range (sheath fluid) and can be integrated into CMOS image sensor directly. Meanwhile, this method provides higher precision of cell image for the later super-resolution reconstruction. The simulation results indicate that more details of cell image can be obtained in this method.