{"title":"索非布韦和利巴韦林联合用药后静脉曲张出血的病例报告","authors":"Sadiq Memon, Madiha Zaki, S. A. Jiskani","doi":"10.21089/NJHS.54.0175","DOIUrl":null,"url":null,"abstract":"Abstract: Sofosbuvir is an oral nucleoside analogue and potent inhibitor of the Hepatitis C virus (HCV) RNA polymerase that is used in combination with other antiviral agents to treat chronic Hepatitis C Nevertheless, and for unknown reasons, successful antiviral therapy of Hepatitis C with Sofosbuvir and other direct acting agents in patients with cirrhosis is occasionally complicated by hepatic decompensation. Here we describe 2 case report of upper gi bleed at initial days of treatment with Sofosbuvir and Ribavirin. Keywords: Variceal bleeding , Sofosdbuvir, Ribavirin, Heptitis C, Nucleoside analogue, Antiviral.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"17 6","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Variceal Bleeding in Patients with Initation of Sofosbuvir and Ribavirin – Case Reports\",\"authors\":\"Sadiq Memon, Madiha Zaki, S. A. Jiskani\",\"doi\":\"10.21089/NJHS.54.0175\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: Sofosbuvir is an oral nucleoside analogue and potent inhibitor of the Hepatitis C virus (HCV) RNA polymerase that is used in combination with other antiviral agents to treat chronic Hepatitis C Nevertheless, and for unknown reasons, successful antiviral therapy of Hepatitis C with Sofosbuvir and other direct acting agents in patients with cirrhosis is occasionally complicated by hepatic decompensation. Here we describe 2 case report of upper gi bleed at initial days of treatment with Sofosbuvir and Ribavirin. Keywords: Variceal bleeding , Sofosdbuvir, Ribavirin, Heptitis C, Nucleoside analogue, Antiviral.\",\"PeriodicalId\":441304,\"journal\":{\"name\":\"National Journal of Health Sciences\",\"volume\":\"17 6\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"National Journal of Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21089/NJHS.54.0175\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"National Journal of Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21089/NJHS.54.0175","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Variceal Bleeding in Patients with Initation of Sofosbuvir and Ribavirin – Case Reports
Abstract: Sofosbuvir is an oral nucleoside analogue and potent inhibitor of the Hepatitis C virus (HCV) RNA polymerase that is used in combination with other antiviral agents to treat chronic Hepatitis C Nevertheless, and for unknown reasons, successful antiviral therapy of Hepatitis C with Sofosbuvir and other direct acting agents in patients with cirrhosis is occasionally complicated by hepatic decompensation. Here we describe 2 case report of upper gi bleed at initial days of treatment with Sofosbuvir and Ribavirin. Keywords: Variceal bleeding , Sofosdbuvir, Ribavirin, Heptitis C, Nucleoside analogue, Antiviral.
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