{"title":"左旋咪唑(NSC-177023)对免疫抑制小鼠淋巴细胞DNA合成的影响。","authors":"W A Woods, M J Filegelman, M A Chirigos","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of in vivo treatment of C57BL mice with BCNU and/or levamisole on the in vitro DNA synthetic capacity of their spleen cells was studied as a measure of cell-mediated immune function. BCNU treatment was suppressive to spleen cell DNA synthesis; conversely, treatment with levamisole was stimulatory. Levamisole treatment 5-8 days after BCNU treatment resulted in significant recovery of DNA synthetic capacity. Multiple doses of levamisole were not more effective than single doses. Allogeneic stimulation of BCNU-suppressed lymphocytes was not consistently increased by levamisole treatment.</p>","PeriodicalId":9510,"journal":{"name":"Cancer chemotherapy reports","volume":"59 3","pages":"531-6"},"PeriodicalIF":0.0000,"publicationDate":"1975-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of levamisole (NSC-177023) on DNA synthesis by lymphocytes from immunosuppressed C57BL mice.\",\"authors\":\"W A Woods, M J Filegelman, M A Chirigos\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of in vivo treatment of C57BL mice with BCNU and/or levamisole on the in vitro DNA synthetic capacity of their spleen cells was studied as a measure of cell-mediated immune function. BCNU treatment was suppressive to spleen cell DNA synthesis; conversely, treatment with levamisole was stimulatory. Levamisole treatment 5-8 days after BCNU treatment resulted in significant recovery of DNA synthetic capacity. Multiple doses of levamisole were not more effective than single doses. Allogeneic stimulation of BCNU-suppressed lymphocytes was not consistently increased by levamisole treatment.</p>\",\"PeriodicalId\":9510,\"journal\":{\"name\":\"Cancer chemotherapy reports\",\"volume\":\"59 3\",\"pages\":\"531-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer chemotherapy reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer chemotherapy reports","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of levamisole (NSC-177023) on DNA synthesis by lymphocytes from immunosuppressed C57BL mice.
The effect of in vivo treatment of C57BL mice with BCNU and/or levamisole on the in vitro DNA synthetic capacity of their spleen cells was studied as a measure of cell-mediated immune function. BCNU treatment was suppressive to spleen cell DNA synthesis; conversely, treatment with levamisole was stimulatory. Levamisole treatment 5-8 days after BCNU treatment resulted in significant recovery of DNA synthetic capacity. Multiple doses of levamisole were not more effective than single doses. Allogeneic stimulation of BCNU-suppressed lymphocytes was not consistently increased by levamisole treatment.
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