猕猴先天性弓形虫感染的实验研究。

Asian journal of infectious diseases Pub Date : 1979-06-01
M M Wong, W J Kozek, S L Karr, M A Brayton, J H Theis, A G Hendrickx
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摘要

以灵长类动物为模型,对猕猴先天性弓形虫病进行了研究。将时间交配的雌性猕猴分为5个实验组,分别在妊娠前和妊娠不同阶段接种4种不同品系的刚地弓形虫。所有的猴子在感染后都表现出间接血凝抗体(IHA)滴度的上升,一些猴子有明显的寄生虫病。在23个子代中,2个死产,2个出生后不久死亡,但只有一个由母体内接种的新生儿死于急性弓形虫病。在任何后代中均未观察到物理异常。弓形虫有机体没有从获得的任何胎盘或脐带血中分离出来。通过小鼠接种,死产或死亡的幼猴的组织中没有弓形虫病阳性。活的后代通常出生时具有高的IHA抗体滴度,但通常很快就会丢失,这表明存在被动获得的母源抗体。然而,在妊娠第79天和第149天感染组织囊肿的母亲所生的2名婴儿,其滴度分别维持了约8个月和19个月的中高滴度,表明发生了活动性感染,但未发现临床疾病。获得的数据表明,尽管弓形虫有机体和胎儿的某些发育阶段可能有利于先天性感染的发生,但在这种灵长类动物模型中,新生儿疾病的发生率非常低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experimental congenital infection of Toxoplasma gondii in Macaca arctoides.

Congenital toxoplasmosis was studied in Macaca arctoides as a model for primates. Time-mated female monkeys were assigned to 5 experimental groups and inoculated with 4 different strains of Toxoplasma gondii before pregnancy and during various stages of gestation. All monkeys showed a rise in indirect hemagglutination antibody (IHA) titers following infection, and some had demonstrable parasitemia. Of the 23 progeny, 2 were stillbirths and 2 died soon after birth, but only the one neonate born of a mother inoculated intrauterally succumbed to acute toxoplasmosis. No physical anomalies were observed in any of the progeny. The toxoplasms organism was not isolated from any of the placentas obtained nor from the cord blood. None of the tissues from the stillborn or infant monkeys that died were positive for toxoplasmosis by mouse inoculation. The live progeny were usually born with high IHA antibody titers which were usually soon lost, indicating presence of passively acquired maternal antibody. However, 2 babies, born of mothers infected with tissue cysts on day 79 and 149 of gestation, maintained moderate to high titers for about 8 and 19 months respectively, indicating that an active infection had taken place but no clinical disease was detected. Data obtained suggest that although certain developmental stages of the toxoplasma organism and of the fetus may favor the occurrence of congenital infection, very little neonatal disease results in this primate model.

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