W W Krueger, H Goepfert, M Romsdahl, J Herson, R H Withers, R H Jesse
{"title":"断裂强度测定表明，成纤维细胞植入可促进伤口愈合。","authors":"W W Krueger, H Goepfert, M Romsdahl, J Herson, R H Withers, R H Jesse","doi":"10.1177/019459987808600527","DOIUrl":null,"url":null,"abstract":"<p><p>Irradiation of normal tissues at the dose/time factor employed in the treatment of solid tumors impairs the subsequent healing of surgical wounds made in those tissues. Irreversible radiation damage to regional fibroblasts is one cause of impaired healing. This study was conducted to determine whether syngeneic guinea pig fibroblasts, harvested from tissue culture when injected into irradiated guinea pig skin at the time of wound closure, could improve wound healing. Breaking strength determinations indicate that irradiated wounds demonstrate enhanced wound healing if implanted with fibroblasts.</p>","PeriodicalId":76297,"journal":{"name":"Otolaryngology","volume":"86 5","pages":"ORL-804-11"},"PeriodicalIF":0.0000,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/019459987808600527","citationCount":"23","resultStr":"{\"title\":\"Fibroblast implantation enhances wound healing as indicated by breaking strength determinations.\",\"authors\":\"W W Krueger, H Goepfert, M Romsdahl, J Herson, R H Withers, R H Jesse\",\"doi\":\"10.1177/019459987808600527\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Irradiation of normal tissues at the dose/time factor employed in the treatment of solid tumors impairs the subsequent healing of surgical wounds made in those tissues. Irreversible radiation damage to regional fibroblasts is one cause of impaired healing. This study was conducted to determine whether syngeneic guinea pig fibroblasts, harvested from tissue culture when injected into irradiated guinea pig skin at the time of wound closure, could improve wound healing. Breaking strength determinations indicate that irradiated wounds demonstrate enhanced wound healing if implanted with fibroblasts.</p>\",\"PeriodicalId\":76297,\"journal\":{\"name\":\"Otolaryngology\",\"volume\":\"86 5\",\"pages\":\"ORL-804-11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/019459987808600527\",\"citationCount\":\"23\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Otolaryngology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/019459987808600527\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Otolaryngology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/019459987808600527","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fibroblast implantation enhances wound healing as indicated by breaking strength determinations.
Irradiation of normal tissues at the dose/time factor employed in the treatment of solid tumors impairs the subsequent healing of surgical wounds made in those tissues. Irreversible radiation damage to regional fibroblasts is one cause of impaired healing. This study was conducted to determine whether syngeneic guinea pig fibroblasts, harvested from tissue culture when injected into irradiated guinea pig skin at the time of wound closure, could improve wound healing. Breaking strength determinations indicate that irradiated wounds demonstrate enhanced wound healing if implanted with fibroblasts.
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