[对抗雌激素的反应作为子宫内膜癌激素敏感性的标准]。

Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles Pub Date : 1978-11-27

P Robel, C Lévy, J P Wolff, J C Nicolas, E E Baulieu

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引用次数: 0

摘要

本文介绍了一种评价子宫内膜癌体内激素敏感性的试验方法。在使用抗雌激素药物他莫昔芬前后，测定了肿瘤组织中黄体酮和雌二醇受体的浓度以及鸟氨酸脱羧酶和17种β -羟类固醇氧化还原酶的活性。观察到的反应，特别是孕激素受体的增加，可以为子宫内膜癌的激素治疗提供更合理的方法。

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[Response to an antiestrogen as a criterion for hormonal sensitivity of endometrial cancer].

A test is described for the evaluation of hormone sensitivity of endometrial cancer in vivo. The concentrations of progesterone and estradiol receptors, and the activities of ornithine-decarboxylase and 17 beta-hydroxysteroid oxido-reductase enzymes have been measured in the tumor, before and after administration of the anti-estrogen tamoxifen. The responses observed, in particular the increase of progesterone receptor, could allow a more rational approach to hormonal therapy of endometrial cancer.

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Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles

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