[中缝大核在吗啡镇痛中的作用:大鼠脑内显微注射的研究]。

Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles Pub Date : 1978-10-23

A H Dickenson, J L Oliveras, J M Besson

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引用次数: 0

摘要

将低浓度的吗啡(5微克)微量注射到大鼠的大鼠核中会产生强烈的镇痛作用，这种镇痛作用可以被全身的纳洛酮(一种阿片类拮抗剂)逆转。纳洛酮(5微克)的管理，以拉斐尔Magnus显著降低静脉注射吗啡的影响。微注射吗啡的效果明显降低，提示5 -羟色胺能机制在吗啡镇痛中的作用。

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[Role of the Raphe Magnus nucleus in morphine analgesia : studies with intracerebral microinjections in the rat].

Microinjections of low concentration of morphine (5 micrograms) into the nucleus Raphé Magnus of the Rat produce a strong analgesia that can be reversed by systemic naloxone, an opiate antagonist. The administration of naloxone (5 micrograms) into the Raphé Magnus considerably reduces the effects of intravenous morphine. The effects of microinjections of morphine are strongly reduced by Cinanserin, suggesting a role for serotoninergic mechanisms in morphine analgesia.

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Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles

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