{"title":"犬骨髓瘤免疫球蛋白轻链可变区氨基酸序列:vk亚群早于哺乳动物物种形成的证据","authors":"Richard L. Wasserman, J. Donald Capra","doi":"10.1016/0161-5890(78)90090-1","DOIUrl":null,"url":null,"abstract":"<div><p>The complete amino acid sequence of the variable region of a kappa light chain derived from a canine myeloma immunoglobulin is presented. The sequence is more than 80% homologous to the human kappa variable region Cum the prototype of the human V<sub>K</sub>II subgroup and is the first example of a non-human kappa chain which can be easily classified as a subgroup other than V<sub>K</sub>I. The finding confirms a previous prediction that genes encoding kappa subgroups predated mammalian speciation.</p></div>","PeriodicalId":13265,"journal":{"name":"Immunochemistry","volume":"15 5","pages":"Pages 303-305"},"PeriodicalIF":0.0000,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-5890(78)90090-1","citationCount":"3","resultStr":"{\"title\":\"The amino acid sequence of the light chain variable region of a canine myeloma immunoglobulin: Evidence that the vk subgroups predated mammalian speciation\",\"authors\":\"Richard L. Wasserman, J. Donald Capra\",\"doi\":\"10.1016/0161-5890(78)90090-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The complete amino acid sequence of the variable region of a kappa light chain derived from a canine myeloma immunoglobulin is presented. The sequence is more than 80% homologous to the human kappa variable region Cum the prototype of the human V<sub>K</sub>II subgroup and is the first example of a non-human kappa chain which can be easily classified as a subgroup other than V<sub>K</sub>I. The finding confirms a previous prediction that genes encoding kappa subgroups predated mammalian speciation.</p></div>\",\"PeriodicalId\":13265,\"journal\":{\"name\":\"Immunochemistry\",\"volume\":\"15 5\",\"pages\":\"Pages 303-305\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-5890(78)90090-1\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0161589078900901\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161589078900901","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The amino acid sequence of the light chain variable region of a canine myeloma immunoglobulin: Evidence that the vk subgroups predated mammalian speciation
The complete amino acid sequence of the variable region of a kappa light chain derived from a canine myeloma immunoglobulin is presented. The sequence is more than 80% homologous to the human kappa variable region Cum the prototype of the human VKII subgroup and is the first example of a non-human kappa chain which can be easily classified as a subgroup other than VKI. The finding confirms a previous prediction that genes encoding kappa subgroups predated mammalian speciation.
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