The role of cytoskeleton in neuron activity.

The extensive cytoskeleton present in brain tissue is composed of microfilaments, neurofilaments, and neurotubules. A clear understanding of each of these structures is required to accurately define their participation in neuronal functions. Until more is known, therefore, we are restricted to speculate on their importance to the general activity of the cell. The presence of microfilamentous proteins in nerve endings -- the sites where nerve transmission is chemically sustained -- strongly suggests their participation in the release of putative neurotransmitters, a hypothesis that may be substantiated in the near future. It follows that alteration in assembly, disassembly, or interaction among the various cytoskeletal components may permit some insight into the causes and origins of a variety of neurological alterations affecting humankind.