硫代氨基脲-过渡金属配合物抑制RNA依赖性DNA聚合酶及劳斯肉瘤病毒的恶性转化能力

William C. Kaska , Carl Carrano , Joseph Michalowski , Jean Jackson , Warren Levinson
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引用次数: 48

摘要

几种硫代氨基脲-金属配合物抑制RNA依赖性DNA聚合酶和劳斯肉瘤病毒的转化能力。有些配合物的活性与自由配体相同,而另一些配合物的活性则大大增强。2-甲酰基吡啶硫代氨基脲铜(II)配合物是我们测试过的这类化合物中最有效的化合物。一些水杨醛衍生物的铜配合物也非常活跃,特别是n-正丁基、n-正己基和n-苄基水杨醛二胺;任何水杨醛化合物的镍配合物均无活性。此外,还测试了其他金属配体,如双硫腙、双乙酰双(巯基乙基亚胺)、n -丁基硫氨基甲酸乙酯、0,0 '二甲基二硫代磷酸、二硫代草酸钾和顺式ptii (NH3)2Cl2,结果各不相同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes

Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0′ dimethyl dithiophosphate, potassium dithiooxalate, and cis-PtII(NH3)2Cl2 were tested with varying results.

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