两种抗组胺化合物(甲喹嗪、右氯苯那敏)对睡眠的影响。抗组胺药引起的睡眠扭曲。

Waking and sleeping Pub Date : 1979-01-01

J L Bassano, E J Caille

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引用次数: 0

摘要

在交叉平衡设计中，12名健康受试者连续7天服用甲喹嗪(每天两次10毫克剂量)、右氯苯那敏(每天两次12毫克剂量)和安慰剂。如果右氯苯那敏引起明显的睡眠扭曲(快速眼动睡眠周期减慢和快速眼动睡眠时间减少)，甲喹嗪则没有类似的趋势，这可能与剂量或时间有关。

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Effects of two antihistaminic compounds (mequitazine, dexchlorpheniramine) on sleep. Sleep distorsion by antihistaminics.

Twelve healthy subjects have been given mequitazine (two 10-milligramme doses a day), dexchlorpheniramine (two 12-milligramme doses a day) and a placebo for seven days, within a cross-over balanced design. If dexchlorpheniramine induces a significant sleep distortion (slowed REM sleep cycle and decreased amount of REM sleep), no similar trend occured with mequitazine, a result that could be dose or time related.

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Waking and sleeping

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