{"title":"褪黑素对α -萘基异硫氰酸盐诱导大鼠肝损伤形成过程中血清胆固醇水平的影响","authors":"Yoshiji Ohta , Yoichiro Imai , Akira Kitagawa","doi":"10.1016/j.ics.2007.07.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>Liver injury with cholestasis<span> appeared 24 h, but not 12 h, after treatment of rats with alpha-naphthylisotiocyanate (ANIT) (75 mg/kg, i.p.). Serum total, free, and estrified cholesterol levels were unchanged at 12 h after ANIT treatment but increases in serum total and free cholesterol levels occurred at 24 h. </span></span>Melatonin<span> (100 mg/kg, p.o.) administered at 12 h after ANIT treatment significantly attenuated these increases at 24 h after the treatment. Thus, melatonin attenuates the disruption of serum cholesterol status with liver injury formation in rats treated with ANIT.</span></p></div>","PeriodicalId":84918,"journal":{"name":"International congress series","volume":"1304 ","pages":"Pages 380-383"},"PeriodicalIF":0.0000,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ics.2007.07.001","citationCount":"0","resultStr":"{\"title\":\"Effect of melatonin on serum cholesterol status with formation of alpha-naphthylisothiocyanate-induced liver injury in rats\",\"authors\":\"Yoshiji Ohta , Yoichiro Imai , Akira Kitagawa\",\"doi\":\"10.1016/j.ics.2007.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Liver injury with cholestasis<span> appeared 24 h, but not 12 h, after treatment of rats with alpha-naphthylisotiocyanate (ANIT) (75 mg/kg, i.p.). Serum total, free, and estrified cholesterol levels were unchanged at 12 h after ANIT treatment but increases in serum total and free cholesterol levels occurred at 24 h. </span></span>Melatonin<span> (100 mg/kg, p.o.) administered at 12 h after ANIT treatment significantly attenuated these increases at 24 h after the treatment. Thus, melatonin attenuates the disruption of serum cholesterol status with liver injury formation in rats treated with ANIT.</span></p></div>\",\"PeriodicalId\":84918,\"journal\":{\"name\":\"International congress series\",\"volume\":\"1304 \",\"pages\":\"Pages 380-383\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ics.2007.07.001\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International congress series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0531513107004086\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International congress series","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0531513107004086","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of melatonin on serum cholesterol status with formation of alpha-naphthylisothiocyanate-induced liver injury in rats
Liver injury with cholestasis appeared 24 h, but not 12 h, after treatment of rats with alpha-naphthylisotiocyanate (ANIT) (75 mg/kg, i.p.). Serum total, free, and estrified cholesterol levels were unchanged at 12 h after ANIT treatment but increases in serum total and free cholesterol levels occurred at 24 h. Melatonin (100 mg/kg, p.o.) administered at 12 h after ANIT treatment significantly attenuated these increases at 24 h after the treatment. Thus, melatonin attenuates the disruption of serum cholesterol status with liver injury formation in rats treated with ANIT.
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