Dita Kadlcikova, Petra Musilova, Hana Hradska, Miluse Vozdova, Marketa Petrovova, Marek Svoboda, Jiri Rubes
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Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods.
The study assessed occupationally induced chromosomal damage in hospital personnel at risk of exposure to antineoplastic drugs and/or low doses of ionizing radiation by two cytogenetic methods. Cultured peripheral blood lymphocytes of eighty-five hospital workers were examined twice over 2 to 3 years by classical chromosomal aberration analysis and fluorescence in situ hybridization. The comparison of the 1st and the 2nd sampling of hospital workers showed a significant increase in chromatid and chromosomal aberrations (all p < .05) examined by classical chromosomal aberration analysis, and in unstable aberrations (all p < .05) detected by fluorescence in situ hybridization. Both cytogenetic methods were able to detect an increase of unstable aberrations in the 2nd sampling. The raised frequency of unstable cytogenetic parameters suggested higher recent exposure to genotoxic agents.
期刊介绍：
Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.
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