未经治疗的极早期类风湿关节炎患者的胰岛素抵抗和不良血脂:一项在中国进行的单中心横断面研究

IF 1.1 4区 医学 Q4 Medicine
Lu Ye, Xin Zhang, Huaxiang Wu, Yahui Chen, Haibo Zhou, Qiaohong Wang, Weihong Xu
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引用次数: 0

摘要

目的:本研究旨在评估未经治疗的极早期类风湿关节炎(RA)患者胰岛素抵抗(IR)的存在及其相关因素。患者和方法:2020年6月至2021年7月,共90例RA患者(男性29例,女性61例;平均年龄49.3±10.2岁;年龄在24至68岁之间)和90名年龄、性别和身体质量指数(BMI)匹配的对照组(男性35名,女性55名;平均年龄:48.3±5.1岁;年龄范围38至62岁)。采用稳态模型评价IR (HOMA-IR)和β细胞功能(HOMA-β)。疾病活动性评分28 (DAS28)用于评估疾病活动性。测量血脂、血红蛋白A1c (HbA1c)、葡萄糖、胰岛素、c反应蛋白(CRP)和红细胞沉降率(ESR)。Logistic回归分析IR与RA患者临床特征的关系。结果:RA患者HOMA-IR值较高(p)。结论:未经治疗的极早期RA患者存在胰岛素抵抗。DAS28、CRP和年龄是IR存在的独立预测因子。基于这些发现,RA患者应及早评估IR的存在,以降低代谢性疾病的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Insulin resistance and adverse lipid profile in untreated very early rheumatoid arthritis patients: A single-center, cross-sectional study in China.

Insulin resistance and adverse lipid profile in untreated very early rheumatoid arthritis patients: A single-center, cross-sectional study in China.

Insulin resistance and adverse lipid profile in untreated very early rheumatoid arthritis patients: A single-center, cross-sectional study in China.

Objectives: This study aims to evaluate the presence and factors related to insulin resistance (IR) in untreated very early rheumatoid arthritis (RA) patients.

Patients and methods: Between June 2020 and July 2021, a total of 90 RA patients (29 males, 61 females; mean age: 49.3±10.2 years; range 24 to 68 years) and 90 age-, sex- and body mass index (BMI)-matched controls (35 males, 55 females; mean age: 48.3±5.1 years; range 38 to 62 years) were included. Homeostatic model assessment was applied to evaluate IR (HOMA-IR) and β-cell function (HOMA-β). Disease activity score 28 (DAS28) was used to estimate disease activity. Lipid profile, hemoglobin A1c (HbA1c), glucose, insulin, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were measured. Logistic regression analysis was performed to investigate the relationship between the IR and clinical features of RA patients.

Results: The RA patients had higher HOMA-IR values (p<0.001) and adverse lipid profile. The IR was positively correlated with age (r=0.35, p<0.01), CRP (r=0.42, p<0.001), ESR (r=0.33, p<0.01), disease duration (r=0.28, p<0.01), and DAS28 (r=0.50, p<0.001). The DAS28, CRP and age, but not sex and menopausal status, were independently associated with IR.

Conclusion: Insulin resistance was present in untreated very early RA patients. The DAS28, CRP, and age were independent predictors for the presence of IR. Based on these findings, RA patients should be evaluated early for the presence of IR to reduce the risk of metabolic diseases.

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来源期刊
Archives of rheumatology
Archives of rheumatology Medicine-Rheumatology
CiteScore
2.00
自引率
9.10%
发文量
15
期刊介绍: The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).
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