部分可吸收缝线的打结强度和抗菌评价。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Chiosa Cletus Odili, Margaret Okonawan Ilomuanya, Olatunde Israel Sekunowo, Oluwashina Philips Gbenebor, Samson Oluropo Adeosun
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引用次数: 2

摘要

部分可吸收缝线对骨科修复是有用的,因为它具有促进强度、降解率和最小炎症之间平衡的能力。然而,部分可吸收缝线的可用性是稀缺的。目前,低密度聚乙烯(LDPE)/聚乳酸(PLA)/壳聚糖(CHS)制备的部分可吸收单丝缝合线的机械强度和抗菌性能尚未见研究;因此,本研究的目的是为了提高结强度、抗菌性能和降解率。本研究采用不同重量分数的LDPE、PLA和CHS挤压单丝缝合线。使用磷酸盐缓冲液(PBS)进行体外降解研究。力学和形态学的变化也被检查。标准傅里叶变换红外光谱分别为3433、2909-2840、1738、1452、1174、1062、706 cm-1,分别为OH基团、C- h拉伸、C=O振动的酯、CH3弯曲、烷基酯和CH2拉伸。与LDPE/PLA/CHS(60/39.5/0.5)相比,打结整齐的LDPE拉伸强度(4.84 MPa)提高了48.7%。这表明,在PLA的重量分数为40%时,可以获得良好的结。单丝缝合线的抗菌性能也较好,LDPE/PLA/CHS(60/39.5/0.5)和LDPE/PLA/CHS(50/49.5/0.5)的抑制区面积为12.7 mm,大于标准的1 mm。随着PLA和CHS的加入,缝合线的形态相显示出暗纤维状的粗糙表面,微观结构不规则,这是增强降解所必需的。因此,本研究制备的部分可吸收缝线可作为肌腱修复的缝线。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Knot strength and antimicrobial evaluations of partially absorbable suture.

Partially absorbable suture is useful for orthopedic repair as it possesses the capacity to promote a balance between strength, degradation rate and minimal inflammation. Still, the availability of partially absorbable suture is scarce. So far, no study has examined the mechanical strength and anti-microbial properties of partially absorbable monofilament suture made of low-density polyethylene (LDPE)/polylactide (PLA)/chitosan (CHS); hence, the reason for this study with a view to improve knot strength, antimicrobial property and degradation rate. In this study, monofilament suture was extruded using different weight fractions of LDPE, PLA and CHS. In vitro degradation studies were carried out using phosphate buffer solution (PBS). Mechanical and morphological changes were also examined. A standard Fourier transform infrared spectral of 3433, 2909-2840, 1738, 1452, 1174, 1062, 706 cm-1 were assigned to OH group, C-H stretch, C=O vibration of ester, CH3 bending, alkyl ester and CH2 stretch, respectively. Tensile strength of knotted neat LDPE (4.84 MPa) exhibited 48.7% improvement in LDPE/PLA/CHS (60/39.5/0.5). This suggests that a good knot can be achieved to 40% weight fraction of PLA. The monofilament suture also demonstrated better antimicrobial property as the monofilament, LDPE/PLA/CHS (60/39.5/0.5) and LDPE/PLA/CHS (50/49.5/0.5) covered 12.7 mm zone of inhibition which is greater than the standard 1 mm. The suture's morphological phases show dark fibre-like rough surfaces with microstructural irregularities as PLA and CHS were added to the matrix, which is required for enhanced degradation. Thus, the partially absorbable suture produced in this study could serve as a suture for tendon repair.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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