InterGEN研究中创伤暴露和DNA甲基化对黑人女性血压的影响

IF 3.2 Q2 GENETICS & HEREDITY
Billy A Caceres, Yunfeng Huang, Veronica Barcelona, Zeyuan Wang, Kevin P Newhall, Jessica P Cerdeña, Cindy A Crusto, Yan V Sun, Jacquelyn Y Taylor
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引用次数: 1

摘要

目的:尽管有证据表明创伤暴露与高血压高风险有关,但创伤可能影响黑人高血压风险的表观遗传机制(如DNA甲基化)仍未得到充分研究。方法:采用黑人母亲纵向研究的数据来验证直接童年创伤(即个人暴露)和间接创伤(即孩子经历的童年创伤)会与DNA甲基化相互作用以增加血压(BP)的假设。在每个CpG位点拟合单独的线性混合效应模型,以DNA甲基化β值和直接和间接创伤为预测因子,以收缩压和舒张压为因变量,根据年龄、吸烟和体重指数进行调整。添加了DNA甲基化β值与直接和间接创伤之间的相互作用项。结果:共纳入244例黑人母亲,平均年龄31.2岁(SD =±5.8)。大约45%的参与者报告至少有一种形式的直接童年创伤,49%报告至少有一种形式的间接创伤。全表观基因组相互作用分析发现,没有CpG位点通过全表观基因组显著水平,表明直接或间接创伤与DNAm的相互作用不影响收缩压或舒张压。结论:这是首次同时研究直接或间接暴露于创伤是否与DNAm相互作用以影响BP的研究之一。虽然研究结果是无效的,但这项研究为未来研究提供了方向,研究可能将创伤暴露与黑人女性高血压风险联系起来的表观遗传机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Interaction of Trauma Exposure and DNA Methylation on Blood Pressure Among Black Women in the InterGEN Study.

The Interaction of Trauma Exposure and DNA Methylation on Blood Pressure Among Black Women in the InterGEN Study.

The Interaction of Trauma Exposure and DNA Methylation on Blood Pressure Among Black Women in the InterGEN Study.

The Interaction of Trauma Exposure and DNA Methylation on Blood Pressure Among Black Women in the InterGEN Study.

Objective: Despite evidence that trauma exposure is linked to higher risk of hypertension, epigenetic mechanisms (such as DNA methylation) by which trauma potentially influences hypertension risk among Black adults remain understudied.

Methods: Data from a longitudinal study of Black mothers were used to test the hypothesis that direct childhood trauma (ie, personal exposure) and vicarious trauma (ie, childhood trauma experienced by their children) would interact with DNA methylation to increase blood pressure (BP). Separate linear mixed effects models were fitted at each CpG site with the DNA methylation beta-value and direct and vicarious trauma as predictors and systolic and diastolic BP modeled as dependent variables adjusted for age, cigarette smoking, and body mass index. Interaction terms between DNA methylation beta-values with direct and vicarious trauma were added.

Results: The sample included 244 Black mothers with a mean age of 31.2 years (SD = ±5.8). Approximately 45% of participants reported at least one form of direct childhood trauma and 49% reported at least one form of vicarious trauma. Epigenome-wide interaction analyses found that no CpG sites passed the epigenome-wide significance level indicating the interaction between direct or vicarious trauma with DNAm did not influence systolic or diastolic BP.

Conclusions: This is one of the first studies to simultaneously examine whether direct or vicarious exposure to trauma interact with DNAm to influence BP. Although findings were null, this study highlights directions for future research that investigates epigenetic mechanisms that may link trauma exposure with hypertension risk in Black women.

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来源期刊
Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
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