血液吸附:溴西泮中毒的一种新的治疗选择。

IF 0.7 Q4 UROLOGY & NEPHROLOGY

Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI:10.1159/000526323

Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar

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引用次数: 1

摘要

苯二氮卓类药物在因中毒而入住ICU的患者中是常见的。一般来说，通过保护气道、呼吸和循环的支持性方法就足够了。氟马西尼是一种众所周知的苯二氮卓类解毒剂，但不影响其消除。根据临床前数据，我们首次将血液吸附过滤器应用于溴西泮中毒患者。这项技术被证明对CHILD-C肝硬化患者消除溴西泮是有效的。我们的结论是，血液吸附是一个可行的选择，以减少ICU的住院时间或插管慢代谢无禁忌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication.

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Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication.

Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam intoxication. This technique proved to be effective in eliminating bromazepam in a patient with CHILD-C cirrhosis. We conclude that hemadsorption is a viable option to reduce length of ICU stay or intubation in slow metabolizers without contraindications.

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来源期刊

Case Reports in Nephrology and Dialysis UROLOGY & NEPHROLOGY-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of nephrology and dialysis, including genetic susceptibility, clinical presentation, diagnosis, treatment or prevention, toxicities of therapy, critical care, supportive care, quality-of-life and survival issues. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed.