测量压力:当前皮质醇和脱氢表雄酮(DHEA)测量技术的回顾和对未来心理健康监测的考虑。

IF 2.6 4区 心理学 Q2 BEHAVIORAL SCIENCES
Tashfia Ahmed, Meha Qassem, Panicos A Kyriacou
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引用次数: 2

摘要

心理压力及其必然导致的精神健康恶化,如临床抑郁症和重度抑郁症,已成为前所未有的全球负担。描述精神疾病特征所涉及的诊断程序通常遵循对压力的定性和主观测量,由于误诊和对这类疾病的严重程度了解不足,往往导致更大的社会经济负担,而围绕精神健康的污名化又进一步加剧了这一负担。近年来,皮质醇和应激激素测量的应用为压力和抑郁的心理评估提供了另一种可量化的方法。这篇综述全面评价了目前最先进的测量皮质醇和脱氢表雄酮(DHEA)的技术及其在人类压力监测中的应用。这些领域的最新进展表明,测量压力激素对于表征人体内压力表现的重要性,以及它与心理健康下降的相关性。考虑多模式压力监测方法的初步研究结果显示了有希望的发展,强调了该领域进一步技术进步的必要性,该领域考虑神经化学和生理压力生物标志物,以实现全球利益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Measuring stress: a review of the current cortisol and dehydroepiandrosterone (DHEA) measurement techniques and considerations for the future of mental health monitoring.

Psychological stress and its inevitable trajectory toward mental health deteriorations such as clinical and major depression has become an unprecedented global burden. The diagnostic procedures involved in the characterization of mental illnesses commonly follow qualitative and subjective measures of stress, often leading to greater socioeconomic burdens due to misdiagnosis and poor understanding of the severity of such illnesses, further fueled by the stigmatization surrounding mental health. In recent years, the application of cortisol and stress hormone measurements has given rise to an alternative, quantifiable approach for the psychological evaluation of stress and depression. This review comprehensively evaluates the current state-of-the-art technology for measuring cortisol and dehydroepiandrosterone (DHEA) and their applications within stress monitoring in humans. Recent advancements in these fields have shown the importance of measuring stress hormones for the characterization of stress manifestation within the human body, and its relevance in mental health decline. Preliminary results from studies considering multimodal approaches toward stress monitoring have showcased promising developments, emphasizing the need for further technological advancement in this field, which consider both neurochemical and physiological biomarkers of stress, for global benefit.

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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
25
审稿时长
6-12 weeks
期刊介绍: The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.
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