辛替单抗和XELOX联合治疗的熟练错配修复(pMMR)晚期结肠癌完全缓解1例。

IF 6.2 Q1 IMMUNOLOGY
Jiangpeng Zhu, Guangyao Li, Zhengjun Zhang, Yandong Wang
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引用次数: 0

摘要

结直肠癌(Colorectal cancer, CRC)是仅次于乳腺癌和肺癌的第三大常见恶性肿瘤,占患者总数的9.4%。有些患者在诊断时已经有远处转移,没有手术机会。延长患者的生存期和提高生活质量尤为重要。患者关注:一名73岁女性因不适超过2个月入院。胸部CT显示左侧锁骨上窝淋巴结肿大。增强腹部CT显示右结肠壁增厚,腹部多发转移性淋巴结。结肠镜显示回盲肿块,病理显示中、低分化腺癌。查体示左侧锁骨上窝见2*2 cm淋巴结。经组织病理及影像学检查,诊断为晚期结肠癌。实际上,很难从根本上进行切除。干预:开始使用辛替单抗联合XELOX。经两期治疗后,顺利行腹腔镜右结肠癌根治术。结果:经转换治疗后,肿大的淋巴结和原发肿瘤明显减少。手术后三周,病人顺利出院。标本及14例淋巴结清扫病理均未见恶性肿瘤。肿瘤消退分级(Tumor regression grading, TRG)为0,表示肿瘤完全消退,无残留肿瘤细胞,包括淋巴结。患者获得病理完全缓解(pCR)。经验教训:本例患者通过上述化疗获得了很大的治疗效益。该病例为pMMR结直肠癌患者使用免疫检查点抑制剂(ICIs)治疗提供了潜在的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Case of Complete Remission in Proficient Mismatch Repair (pMMR) Advanced Colon Cancer Treated with Sintilimab and XELOX.

A Case of Complete Remission in Proficient Mismatch Repair (pMMR) Advanced Colon Cancer Treated with Sintilimab and XELOX.

A Case of Complete Remission in Proficient Mismatch Repair (pMMR) Advanced Colon Cancer Treated with Sintilimab and XELOX.

A Case of Complete Remission in Proficient Mismatch Repair (pMMR) Advanced Colon Cancer Treated with Sintilimab and XELOX.

Introduction: Colorectal cancer (CRC) is the 3rd most common malignant tumors after breast cancer and lung cancer, accounting for 9.4% of patients. Some patients had distant metastasis at the time of diagnosis without surgery opportunity. It is particularly important to prolong patient survival and improve quality of life.

Patient concerns: A 73-year-old female was admitted with discomfort over 2 months. Enlarged lymph nodes in the left supraclavicular fossa were observed in chest computed tomography (CT). Enhanced abdominal CT showed thickening of the right colon wall with multiple metastatic lymph nodes in the abdomen. Colonoscopy showed ileocecal mass and pathology showed moderately and poorly differentiated adenocarcinoma. Physical examination showed a 2*2 cm lymph node could be touched in the left supraclavicular fossa. The patient was diagnosed advanced colon cancer by the histopathological examination and imaging findings. Actually, it is hardly to resect radically.

Intervention: Sintilimab combined with XELOX was initiated. Two period of treatment after initial therapy, laparoscopic radical resection of right colon cancer was performed successfully.

Outcomes: After conversion treatment, the enlarged lymph nodes and primary tumor were significantly reduced. The patient was discharged successfully three weeks after surgery. Both specimen and 14 lymph nodes dissected showed no malignancy in pathology. Tumor regression grading (TRG) is 0, which indicate complete regression with no residual tumor cells including lymph nodes. The patient obtained a pathological complete response (pCR).

Lessons: The patient achieved a great therapeutic benefit with the above-mentioned chemotherapy in this case. The case provides a potential reference for pMMR CRC patients treating with immune checkpoint inhibitors (ICIs).

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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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