新的 1H-吡唑并[3,4-d]嘧啶-1-基)乙基)-2-苯基异喹啉-1(2H)-酮作为治疗癌症和其他疾病的磷酸肌酸 3-激酶抑制剂。

IF 2.5 4区医学 Q3 ONCOLOGY

Recent patents on anti-cancer drug discovery Pub Date : 2024-01-01 DOI:10.2174/1574892818666230228153103

Surya K De

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引用次数: 0

摘要

本专利描述了新型有用化合物，如 PI3K 蛋白激酶抑制剂，特别是 PI3K δ (δ) 和/或 γ (γ) 蛋白激酶调节剂。本公开还提供了制备 PI3K 蛋白激酶抑制剂的方法、含有这些抑制剂的药物组合物，以及治疗、预防和改善 PI3K 激酶介导的疾病和失调的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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New 1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-phenylisoquinoline-1(2H)-ones as Phosphoinositide 3-kinase Inhibitors for Treating Cancer and Other Diseases.

The patent describes novel useful compounds, such as PI3K protein kinase inhibitors, in particular as PI3K delta (δ) and/or gamma (γ) protein kinase modulators. The present disclosure also provides methods for preparing PI3K protein kinase inhibitors, pharmaceutical compositions containing them, and methods of treatment, prevention, and amelioration of PI3K kinase-mediated diseases, and disorders.

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来源期刊

Recent patents on anti-cancer drug discovery 医学-药学

CiteScore

4.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.