线粒体动力学和氧化磷酸化是癌症的关键靶点。

IF 4.1 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Kaylee B Punter, Charles Chu, Edmond Y W Chan
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引用次数: 1

摘要

人们早就认识到,癌细胞严重依赖于代谢的重编程模式,这种模式可以实现稳健和异常高水平的细胞增殖。由于线粒体形成了细胞代谢活动的中枢,因此有理由提出,这些细胞器内的途径可以形成靶标,这些靶标可以被操纵以损害癌细胞引起疾病的能力。然而,线粒体是高度多功能的,并且完整的机制相互联系仍在被揭示,以实现靶向线粒体在癌症治疗中的全部潜力。在这里,我们的目的是强调调节线粒体动力学的潜力,以针对癌细胞中的关键代谢或凋亡途径。线粒体裂变和融合在不同的癌症环境中发挥着不同的作用。靶向介导线粒体动力学的因子可能与氧化磷酸化的损伤直接相关,氧化磷酸化是维持癌细胞生长所必需的,也可以改变对化疗药物的敏感性。这一领域仍然缺乏一个统一的模型,尽管进一步的研究将更全面地绘制潜在的分子机制,以基于这些途径实现更好的合理治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitochondrial dynamics and oxidative phosphorylation as critical targets in cancer.

It has long been recognised that cancer cells critically depend on reprogrammed patterns of metabolism that can enable robust and abnormally high levels of cell proliferation. As mitochondria form hubs of cellular metabolic activity, it is reasonable to propose that pathways within these organelles can form targets that can be manipulated to compromise the ability of cancer cells to cause disease. However, mitochondria are highly multi-functional, and the full range of mechanistic inter-connections are still being unravelled to enable the full potential of targeting mitochondria in cancer therapeutics. Here, we aim to highlight the potential of modulating mitochondrial dynamics to target key metabolic or apoptotic pathways in cancer cells. Distinct roles have been demonstrated for mitochondrial fission and fusion in different cancer contexts. Targeting of factors mediating mitochondrial dynamics may be directly related to impairment of oxidative phosphorylation, which is essential to sustain cancer cell growth and can also alter sensitivity to chemotherapeutic compounds. This area is still lacking a unified model, although further investigation will more comprehensively map the underlying molecular mechanisms to enable better rational therapeutic strategies based on these pathways.

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来源期刊
Endocrine-related cancer
Endocrine-related cancer 医学-内分泌学与代谢
CiteScore
7.80
自引率
2.60%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Endocrine-Related Cancer is an official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, the United Kingdom and Ireland Neuroendocrine Society, and the Japanese Hormones and Cancer Society. Endocrine-Related Cancer provides a unique international forum for the publication of high quality original articles describing novel, cutting edge basic laboratory, translational and clinical investigations of human health and disease focusing on endocrine neoplasias and hormone-dependent cancers; and for the publication of authoritative review articles in these topics. Endocrine neoplasias include adrenal cortex, breast, multiple endocrine neoplasia, neuroendocrine tumours, ovary, prostate, paraganglioma, parathyroid, pheochromocytoma pituitary, testes, thyroid and hormone-dependent cancers. Neoplasias affecting metabolism and energy production such as bladder, bone, kidney, lung, and head and neck, are also considered.
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