18F-FDG PET/CT技术评估棕色脂肪组织:最新综述

Expert review of medical devices Pub Date : 2023-07-01 Epub Date: 2023-11-24 DOI:10.1080/17434440.2023.2283618
Maria Ricci, Maria Silvia De Feo, Giorgia Maria Granese, Viviana Frantellizzi, Bruno Carabellese, Ennio Lubrano, Andrea Cimini
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引用次数: 0

摘要

简介:本文综述了用于Brown aditissue (BAT)活性定量的18F -fluorodeoxyglucose ([18F] FDG)的最新进展,其作用尚不完全清楚。涉及领域:我们对文献进行了非结构化检索,以查找在BAT评估中使用[18F] FDG PET的任何研究。我们探索了BAT在健康个体和不同病理、冷暴露后以及作为代谢生物标志物的量化。图中显示了使用[18F] FDG PET对可能的BAT调制剂的评估。进一步的PET示踪剂和BAT评估的新发展也被描述。专家意见:进一步的PET示踪剂和成像方式正在研究中,但[18F] FDG PET是目前评估BAT的首选方法,需要进一步的多中心试验来更好地了解BAT的生理病理,也需要在冷刺激后。[18F] FDG PET成像评估了BAT活性的调节,似乎是治疗肥胖和2型糖尿病等疾病的一种很有前途的工具。此外,BAT激活与癌症患者预后[18F] FDG PET指数之间可能存在有趣的相关性,需要通过进一步的多中心试验来评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
18F-FDG PET/CT technology for the assessment of brown adipose tissue: an updated review.

Introduction: This review provides an update of 18 F-fluorodeoxyglucose ([18F] FDG) for Brown adipose tissue (BAT) activity quantification, whose role is not completely understood.

Areas covered: We conducted an unstructured search of the literature for any studies employing the [18F] FDG PET in BAT assessment. We explored BAT quantification both in healthy individuals and in different pathologies, after cold exposure and as a metabolic biomarker. The assessment of possible BAT modulators by using [18F] FDG PET is shown. Further PET tracers and novel developments for BAT assessments are also described.

Expert opinion: Further PET tracers and imaging modalities are under investigation, but the [18F] FDG PET is currently the method of choice for the evaluation of BAT and further multicentric trials are needed for a better understanding of the BAT physiopathology, also after cold stimuli. The modulation of BAT activity, assessed by [18F] FDG PET imaging, seems a promising tool for the management of conditions such as obesity and type 2 diabetes. Moreover, an interesting possible correlation of BAT activation with prognostic [18F] FDG PET indices in cancer patients should be assessed with further multicentric trials.

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