Tatjana Barišić, Marjana Jerković Raguž, Ivona Šušak, Emil Babić, Svjetlana Grgić, Iva Mandić
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引用次数: 0
摘要
背景:探讨促甲状腺素水平升高与流产频率的关系。方法:采用横断面研究方法，对380名被调查者进行流产孕妇(179例)和正常妊娠孕妇(201例)的TSH(促甲状腺激素)、甲状腺过氧化物酶抗体(anti-TPO)和游离甲状腺素(FT4)的检测。结果:与抗tpo抗体阳性和TSH < 2.5mIU/L(14.15%)相比，流产组亚临床甲状腺功能减退发生率(61.4% vs 15.79%)高于对照组(p < 0.05)。结论:TSH水平升高与妊娠早期肥胖相关，可能是母体甲状腺功能障碍的标志。妊娠前三个月的生理性甲状腺功能对围产期结局很重要。
Do elevated thyrotropin levels increase the risk of miscarriages: yes or no?
Background: To examine correlation between elevated levels of thyrotropin with the frequency of miscarriages.
Methods: A cross-sectional study was conducted on the 380 respondents and it investigated TSH (thyrotropin), thyroid peroxidase antibody(anti-TPO) and free thyroxine (FT4) in pregnant women who had a miscarriage (N = 179) and pregnant women with normal pregnancies (N = 201).
Results: The incidence of subclinical hypothyroidism in the miscarriages group was higher than in control group (61.4% vrs 15.79% (p < 0.001). In the miscarriages group with hypothyroidism (first trimester) mean value of TSH was significantly higher 4.31 ± 2.55 mIU/L compared to the control group 1.95 ± 0.86mIU/L (p < 0.001). Logistic multivariate regression revealed that TSH and body mass index (BMI) have a significant influence on the miscarriage; TSH level has a higher odds ratio (OR) 1.47 CI (95% 1.22-1.78) than BMI (OR) 1.14 CI (95% 1.06-1.23)) (p < 0.001). The combination of thyroid autoimmunity and TSH > 2.5mIU/L increase the risk of miscarriage (65.75%) compared to positive anti-TPO antibodies and TSH < 2.5mIU/L(14.15%)(p < 0.001).
Conclusions: Higher TSH levels correspond with obesity during early pregnancy and may be a sign of maternal thyroid dysfunction. Physiological thyroid function in the first trimester of pregnancy is important for perinatal outcome.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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