一种药物-药物共晶和共无定形，由厚朴酚和川芎嗪制成，灵感来自中成药。

IF 1.3 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Acta crystallographica Section B, Structural science, crystal engineering and materials Pub Date : 2023-12-01 Epub Date: 2023-11-15 DOI:10.1107/S2052520623008648

Yanli Zhang, Hui Liu, Zongxin Chen, Jialei Meng, Yunfeng Li, Luyao Qi, Suiliang Zhang, Xiaofeng Chen, Ming Lei

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引用次数: 0

摘要

合成并表征了一种由两种抗血栓活性成分——厚朴酚(honokiol, HON)和川芎嗪(川芎嗪，TMP, 1:1)组成的药物-药物共晶体。通过单晶x射线衍射测定了HON-TMP(1:1)的结构。然后，以中成药十君子蜂蜜丸的研磨工艺为灵感，采用蜂蜜辅助研磨法制备了共无定形的HON-TMP。这种共无定形药物-药物共晶(20%蜂蜜)在HON上表现出更好的溶解度，并且比TMP显着降低升华倾向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A drug-drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine.

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A drug-drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine.

A drug-drug cocrystal created with two antithrombotic-active ingredients from herbs, honokiol (HON) and ligustrazine (TMP, 1:1), was synthesized and characterized. The structure of HON-TMP (1:1) was determined by single-crystal X-ray diffraction. Then co-amorphous HON-TMP was prepared by honey-assisted grinding, which was inspired by a grinding process for a Chinese patent medicine-Shijunzi honey pill. This co-amorphous drug-drug cocrystal (20% honey) exhibits improved solubility over HON and a significantly reduced sublimation tendency than TMP.

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来源期刊

Acta crystallographica Section B, Structural science, crystal engineering and materials CHEMISTRY, MULTIDISCIPLINARYCRYSTALLOGRAPH-CRYSTALLOGRAPHY

CiteScore

3.60

自引率

5.30%

发文量

期刊介绍： Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials publishes scientific articles related to the structural science of compounds and materials in the widest sense. Knowledge of the arrangements of atoms, including their temporal variations and dependencies on temperature and pressure, is often the key to understanding physical and chemical phenomena and is crucial for the design of new materials and supramolecular devices. Acta Crystallographica B is the forum for the publication of such contributions. Scientific developments based on experimental studies as well as those based on theoretical approaches, including crystal-structure prediction, structure-property relations and the use of databases of crystal structures, are published.