非酒精性脂肪性肝病与肝脏分泌组

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL
Muhammad Sohaib Khan, Choongho Lee, Sang Geon Kim
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引用次数: 3

摘要

碳水化合物和脂质的代谢以及蛋白质的降解发生在肝脏中,并通过分泌多种介质来促进身体的内稳态。由于过量脂肪消耗和伴随脂肪毒性、自噬失调、内质网应激和胰岛素抵抗的病理事件而导致的任何体内平衡失衡,都可能导致肝脏蛋白质分泌紊乱,以及它们的生理改变和相互作用。由于肝脏分泌组不仅在肝脏本身,而且在其他器官中都起着调节燃料代谢和炎症的作用,因此这些蛋白质属于治疗代谢性和炎症性疾病(例如COVID-19)的最大靶点,这取决于控制其生物效应的可用和可行方法。然而,在这个时代,我们仍然发现了新的肝源性蛋白质,但仍无法完全了解疾病进展的病理基础。本文综述了肝脏分泌组生物学的最新进展,以及代谢和炎症性肝病进展的解释机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Non-alcoholic fatty liver disease and liver secretome

Non-alcoholic fatty liver disease and liver secretome

Metabolism of carbohydrates and lipids and protein degradation occurs in the liver and contributes to the body's homeostasis by secreting a variety of mediators. Any imbalance in this homeostasis due to excess fat consumption and the pathologic events accompanying lipotoxicity, autophagy dysregulation, endoplasmic reticulum stress, and insulin resistance may cause disturbances in the secretion of the proteins from the liver and their physiologic modifications and interactions with others. Since the liver secretome plays a role in the regulation of fuel metabolism and inflammation not only in the liver per se but also in other organs, the proteins belong to the utmost targets for treating metabolic and inflammatory diseases (e.g., COVID-19), depending on the available and feasible approaches to controlling their biological effects. However, in this era, we still come across new liver-derived proteins but are yet unable to entirely understand the pathologic basis underlying disease progression. This review aims to provide an updated overview of liver secretome biology with explanatory mechanisms with regard to the progression of metabolic and inflammatory liver diseases.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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