高压氧治疗对辐照患者皮肤弹性的影响。

IF 0.8 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Diving and hyperbaric medicine Pub Date : 2022-09-30 DOI:10.28920/dhm52.3.208-212

Karan Pandey, David N Teguh, Robert A van Hulst

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引用次数: 0

摘要

背景：高压氧治疗（HBOT）通常用于逆转/治疗晚期放射性诱导的组织纤维化（LRITF）。这项研究旨在量化对皮肤弹性的影响。方法：用皮肤回缩时间作为13例癌症放疗后皮肤弹性指标。在镜像位置对受影响侧以及未受影响/健康侧进行测量。在HBOT开始和结束时进行读数（平均43次，在243kPa下80分钟）。结果：患者年龄在39-70岁之间。所有患者在接受HBOT之前均接受了肿瘤切除术和放射治疗。放疗与HBOT的平均间隔时间为70个月。13名患者中有7人接受了化疗。平均照射皮肤回缩时间从HBOT前的417（SD 158）改善到HBOT后的171（24）毫秒（P＜0.001）。未照射皮肤的平均照射前回缩时间为143（20）毫秒，没有变化。结论：这项有前景的初步研究表明，HBOT可以改善LRITF患者的皮肤弹性。

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Effect of hyperbaric oxygen treatment on skin elasticity in irradiated patients.

Background: Hyperbaric oxygen treatment (HBOT) is often used in an attempt to reverse/treat late radiation-induced tissue fibrosis (LRITF). This study aimed to quantify the effects on skin elasticity.

Methods: Skin retraction time was used as a marker of skin elasticity in 13 irradiated breast cancer patients. The measurements were carried out on the affected side as well as the unaffected/healthy side at a mirrored location. Readings were taken at the start and end of HBOT (mean 43 sessions, 80 min at 243 kPa).

Results: Patient age ranged from 39-70 years. All patients underwent surgical lumpectomy and radiotherapy prior to undergoing HBOT. The mean time between radiotherapy and HBOT was 70 months. Seven of the 13 patients underwent chemotherapy. Mean irradiated skin retraction time improved from 417 (SD 158) pre-HBOT to 171 (24) msec post-HBOT (P < 0.001). Mean pre-HBOT retraction time in the non-irradiated skin was 143 (20) msec and did not change.

Conclusions: This promising pilot study that suggests that HBOT may improve skin elasticity in patients with LRITF.

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来源期刊

Diving and hyperbaric medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

1.70

自引率

22.20%

发文量

审稿时长

>12 weeks

期刊介绍： Diving and Hyperbaric Medicine (DHM) is the combined journal of the South Pacific Underwater Medicine Society (SPUMS) and the European Underwater and Baromedical Society (EUBS). It seeks to publish papers of high quality on all aspects of diving and hyperbaric medicine of interest to diving medical professionals, physicians of all specialties, scientists, members of the diving and hyperbaric industries, and divers. Manuscripts must be offered exclusively to Diving and Hyperbaric Medicine, unless clearly authenticated copyright exemption accompaniesthe manuscript. All manuscripts will be subject to peer review. Accepted contributions will also be subject to editing.