精液质量、精子DNA完整性与职业接触多环芳烃相关性的混合分析。

IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES
Hueiwang Anna Jeng, Sinjini Sikdar, Chih-Hong Pan, Mu-Rong Chao, Guo-Ping Chang-Chien, Wen-Yi Lin
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引用次数: 3

摘要

本研究的目的是评估职业水平的多环芳烃暴露与人类精液质量和精子DNA完整性之间的关系。收集了个人呼吸区空气样本,以量化台湾南部一家钢铁公司焦炉工人接触到的16种目标多环芳烃。评估精液质量,包括浓度、活力、形态和活力。精子DNA片段化、8-氧-郭、大体积多环芳烃加合物和苯并[a]芘二醇环氧化物-DNA加合物可作为评估精子DNA完整性的生物标志物。采用贝叶斯核机回归模型估计多环芳烃混合物对精液质量和精子DNA完整性的混合效应,并确定与混合效应相关的多环芳烃混合物的单个化合物。暴露于多环芳烃混合物与精子活力呈负相关,而苯并(b)荧光蒽(b [b]F)被确定为精子活力的主要预测因子。暴露于多环芳烃混合物中也表现出与精子DNA断裂呈正相关的趋势。B[B]F和苯并(a)蒽(B[a] a)被确定为与精子DNA断裂增加有关的单个多环芳烃化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mixture analysis on associations between semen quality and sperm DNA integrity and occupational exposure to polycyclic aromatic hydrocarbons.

The objective of this study was to assess relationships between exposure to PAHs at occupational levels and outcomes of human semen quality and sperm DNA integrity. Personal breathing zone air samples were collected to quantify exposure of 16 targeted PAHs to coke-oven workers at a steel company in southern Taiwan. Semen quality, including concentration, motility, morphology, and viability, were assessed. Sperm DNA fragmentation, 8-oxodGuo, bulky PAH adducts, and benzo[a]pyrene diol epoxide-DNA adducts served as biomarkers for assessment of sperm DNA integrity. The Bayesian Kernel Machine Regression modeling was employed to estimate mixture effects of the PAH mixture on the outcomes of semen quality and sperm DNA integrity and to identify individual compounds of PAH mixtures associated with the mixture effects. Exposure to the PAH mixture was inversely associated with sperm viability, while benzo(b)fluoranthene (B[b]F) was identified as the main predictor for sperm viability. Exposure to the PAH mixture also exhibited a positive trend with sperm DNA fragmentation. B[b]F and benzo(a)anthracene (B[a]A) were identified as individual PAH compounds associated with increased sperm DNA fragmentation.

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来源期刊
Archives of Environmental & Occupational Health
Archives of Environmental & Occupational Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
3.70
自引率
0.00%
发文量
33
审稿时长
>36 weeks
期刊介绍: Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.
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