Alice Regina Costa Barbosa, Daniella Pires Nunes, Daniela Braga Lima, Fabio Antonio Colombo, Juliana Barbosa Nunes, Ariene Angelini Dos Santos Orlandi, Greiciane da Silva Rocha, Daniele Sirineu Pereira, Ligiana Pires Corona, Tábatta Renata Pereira de Brito
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引用次数: 0
摘要
考虑到端粒长度不仅可以由与细胞生物学相关的问题决定,还可以由与社会因素和环境暴露相关的方面决定,研究社会因素与端粒长度之间的关系有助于更好地理解人类衰老过程中尚不为人所知的方面。因此,本研究旨在验证社会支持网络是否与老年人的端粒长度有关。这是一项横断面研究,研究对象为448名年龄在60岁以上的巴西内陆城市居民。通过实时qPCR获得端粒长度的相对定量。社会支持通过医疗结果研究社会支持量表进行评估。数据分析采用描述性统计和多元逻辑回归。被评估的老年人社会支持网络平均由16.4人组成,老年人在网络中报告多达5名成员的比例为27.75%。25%的参与者发现端粒长度较短,报告有多达五名支持网络成员的老年人比报告网络数量更多的老年人更可能具有较短的端粒长度(优势比:1.89, p = 0.011),与性别、年龄、家庭安排、认知能力下降以及对日常生活基本和工具活动的依赖无关,这表明应该采取措施刺激社会支持网络的建立和维持,以改善老年人的健康。
Association of Social Support Network with Telomere Length: A Cross-Sectional Study with Community-Dwelling Older Adults.
Considering that telomere length can be determined not only by issues related to cell biology but also by aspects related to social factors and environmental exposures, studies on the relationship between social aspects and telomere length can help to better understand the still scarcely known aspects of the human aging process. Thus, this research seeks to verify whether social support networks are associated with telomere length in older adults. This is a cross-sectional study conducted with 448 individuals aged at least 60 years living in the urban area of an inland Brazilian municipality. Relative quantification of telomere length was obtained through real-time qPCR. Social support was assessed through the Medical Outcomes Study Social Support Scale. Descriptive statistics and multiple logistic regression were used in data analysis. The evaluated social support networks for older adults consist in a mean of 16.4 people, and the percentage of older adults who reported up to five members in their network was 27.75%. Shorter telomere length was identified in 25% of the participants, and the older adults who reported having up to five members in their support network were more likely to have a shorter telomere length than those who reported more numerous networks (odds ratio: 1.89, p = 0.011) regardless of gender, age, household arrangement, cognitive decline, and dependence for basic and instrumental activities of daily living, which suggests that measures that stimulate the creation and maintenance of social support networks should be implemented to improve older adults' health.
期刊介绍:
Rejuvenation Research publishes cutting-edge, peer-reviewed research on rejuvenation therapies in the laboratory and the clinic. The Journal focuses on key explorations and advances that may ultimately contribute to slowing or reversing the aging process, and covers topics such as cardiovascular aging, DNA damage and repair, cloning, and cell immortalization and senescence.
Rejuvenation Research coverage includes:
Cell immortalization and senescence
Pluripotent stem cells
DNA damage/repair
Gene targeting, gene therapy, and genomics
Growth factors and nutrient supply/sensing
Immunosenescence
Comparative biology of aging
Tissue engineering
Late-life pathologies (cardiovascular, neurodegenerative and others)
Public policy and social context.