小鼠透明带蛋白作为精子与卵子结合的受体。

Trends in developmental biology Pub Date : 2022-01-01
Paul M Wassarman, Eveline S Litscher
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引用次数: 0

摘要

哺乳动物的受精是由受物种限制的自由游动的精子与未受精卵的厚细胞外基质透明带(ZP)结合而开始的。顶体完整精子和顶体反应精子都能与ZP结合,但只有后者能穿透ZP,到达卵子的质膜,与质膜融合(受精)产生受精卵。受精后,ZP被皮质颗粒成分修饰,使顶体完整和顶体反应的精子不能与受精卵结合。本文回顾了两种小鼠ZP蛋白mZP2和mZP3作为受体参与小鼠精子与未受精卵结合的一些直接证据,并解决了围绕哺乳动物受精过程中这一重要初始步骤的一些有争议的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mouse zona pellucida proteins as receptors for binding of sperm to eggs.

Mouse zona pellucida proteins as receptors for binding of sperm to eggs.

Mouse zona pellucida proteins as receptors for binding of sperm to eggs.

Fertilization in mammals is initiated by species-restricted binding of free-swimming sperm to the unfertilized egg's thick extracellular matrix, the zona pellucida (ZP). Both acrosome-intact and acrosome-reacted sperm can bind to the ZP, but only the latter can penetrate the ZP, reach the egg's plasma membrane, and fuse with plasma membrane (fertilization) to produce a zygote. Following fertilization, the ZP is modified by cortical granule components such that acrosome-intact and acrosome-reacted sperm are unable to bind to fertilized eggs. Here we review some of the evidence that bears directly on the involvement of two mouse ZP proteins, mZP2 and mZP3, as receptors for binding of mouse sperm to unfertilized eggs and address some contentious issues surrounding this important initial step in the process of mammalian fertilization.

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