Sandra Sanchez-Roige, Samuel A. Barnes, Jazlene Mallari, Rebecca Wood, Oksana Polesskaya, Abraham A. Palmer
{"title":"糖蛋白M6-B (Gpm6b)的突变等位基因促进行为灵活性,但增加延迟折扣","authors":"Sandra Sanchez-Roige, Samuel A. Barnes, Jazlene Mallari, Rebecca Wood, Oksana Polesskaya, Abraham A. Palmer","doi":"10.1111/gbb.12800","DOIUrl":null,"url":null,"abstract":"<p>The neuronal membrane glycoprotein M6B (<i>Gpm6b</i>) gene encodes a membrane glycoprotein that belongs to the proteolipid protein family, and is enriched in neurons, oligodendrocytes, and subset of astrocytes in the central nervous system. GPM6B is thought to play a role in neuronal differentiation, myelination, and inactivation of the serotonin transporter via internalization. Recent human genome-wide association studies (GWAS) have implicated membrane glycoproteins (both <i>GPM6B</i> and <i>GPM6A</i>) in the regulation of traits relevant to psychiatric disorders, including neuroticism, depressed affect, and delay discounting. Mouse studies have implicated <i>Gpm6b</i> in sensorimotor gating and regulation of serotonergic signaling. We used CRISPR to create a mutant Glycoprotein M6B (<i>Gpm6b</i>) allele on a C57BL/6J mouse background. Because <i>Gpm6b</i> is located on the X chromosome, we focused on male <i>Gpm6b</i> mutant mice and their wild-type littermates (WT) in two behavioral tests that measured aspects of impulsive or flexible decision-making. We found that <i>Gpm6b</i> deletion caused deficits in a delay discounting task. In contrast, reward sensitivity was enhanced thereby facilitating behavioral flexibility and improving performance in the probabilistic reversal learning task. Taken together these data further delineate the role of <i>Gpm6b</i> in decision making behaviors that are relevant to multiple psychiatric disorders.</p>","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"21 4","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/e1/GBB-21-e12800.PMC9211103.pdf","citationCount":"2","resultStr":"{\"title\":\"A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting\",\"authors\":\"Sandra Sanchez-Roige, Samuel A. Barnes, Jazlene Mallari, Rebecca Wood, Oksana Polesskaya, Abraham A. Palmer\",\"doi\":\"10.1111/gbb.12800\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The neuronal membrane glycoprotein M6B (<i>Gpm6b</i>) gene encodes a membrane glycoprotein that belongs to the proteolipid protein family, and is enriched in neurons, oligodendrocytes, and subset of astrocytes in the central nervous system. GPM6B is thought to play a role in neuronal differentiation, myelination, and inactivation of the serotonin transporter via internalization. Recent human genome-wide association studies (GWAS) have implicated membrane glycoproteins (both <i>GPM6B</i> and <i>GPM6A</i>) in the regulation of traits relevant to psychiatric disorders, including neuroticism, depressed affect, and delay discounting. Mouse studies have implicated <i>Gpm6b</i> in sensorimotor gating and regulation of serotonergic signaling. We used CRISPR to create a mutant Glycoprotein M6B (<i>Gpm6b</i>) allele on a C57BL/6J mouse background. Because <i>Gpm6b</i> is located on the X chromosome, we focused on male <i>Gpm6b</i> mutant mice and their wild-type littermates (WT) in two behavioral tests that measured aspects of impulsive or flexible decision-making. We found that <i>Gpm6b</i> deletion caused deficits in a delay discounting task. In contrast, reward sensitivity was enhanced thereby facilitating behavioral flexibility and improving performance in the probabilistic reversal learning task. 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A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting
The neuronal membrane glycoprotein M6B (Gpm6b) gene encodes a membrane glycoprotein that belongs to the proteolipid protein family, and is enriched in neurons, oligodendrocytes, and subset of astrocytes in the central nervous system. GPM6B is thought to play a role in neuronal differentiation, myelination, and inactivation of the serotonin transporter via internalization. Recent human genome-wide association studies (GWAS) have implicated membrane glycoproteins (both GPM6B and GPM6A) in the regulation of traits relevant to psychiatric disorders, including neuroticism, depressed affect, and delay discounting. Mouse studies have implicated Gpm6b in sensorimotor gating and regulation of serotonergic signaling. We used CRISPR to create a mutant Glycoprotein M6B (Gpm6b) allele on a C57BL/6J mouse background. Because Gpm6b is located on the X chromosome, we focused on male Gpm6b mutant mice and their wild-type littermates (WT) in two behavioral tests that measured aspects of impulsive or flexible decision-making. We found that Gpm6b deletion caused deficits in a delay discounting task. In contrast, reward sensitivity was enhanced thereby facilitating behavioral flexibility and improving performance in the probabilistic reversal learning task. Taken together these data further delineate the role of Gpm6b in decision making behaviors that are relevant to multiple psychiatric disorders.
期刊介绍:
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