{"title":"面临前欧米克龙和欧米克龙 COVID-19 流行病的血液透析患者的疗效比较。","authors":"Hiroko Beppu, Tatsuya Fukuda, Naoya Otsubo, Taro Akihisa, Tomoko Kawanishi, Toshie Ogawa, Yasutomo Abe, Mariko Endo, Tomohide Hanawa, Chise Sugita, Yoshiaki Kikkawa, Tetsuya Yamada, Sachiko Wakai","doi":"10.1111/1744-9987.14067","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study elucidates factors affecting the severity and mortality in pre-Omicron and Omicron strains of SARS-CoV-2 and vaccination impact.</p><p><strong>Methods: </strong>This single-center retrospective observational study included 1598 hospitalized COVID-19 patients. Patients were grouped into \"pre-Omicron\" and \"Omicron\" periods. The endpoint was severe COVID-19 (oxygen saturation [SpO<sub>2</sub> ] < 94%). Logistic regression examined associations between clinical factors, including hemodialysis (HD), and the endpoint.</p><p><strong>Results: </strong>The HD patient mortality rate dropped from 16% pre-Omicron to 4% during the Omicron epidemic. HD was significantly associated with the study endpoint in both epidemics. Unvaccinated patients had a greater risk of reaching the study endpoint among patients receiving HD.</p><p><strong>Conclusion: </strong>These findings suggest that the Omicron variant, alongside vaccination and healthcare innovations, led to improved prognoses for HD patients with COVID-19. However, HD patients remain at a greater risk for severe COVID-19. Increased vaccination rates and optimized healthcare resources can improve this vulnerable population's prognoses.</p>","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":" ","pages":"51-60"},"PeriodicalIF":1.5000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative outcomes of hemodialysis patients facing pre-Omicron and Omicron COVID-19 epidemics.\",\"authors\":\"Hiroko Beppu, Tatsuya Fukuda, Naoya Otsubo, Taro Akihisa, Tomoko Kawanishi, Toshie Ogawa, Yasutomo Abe, Mariko Endo, Tomohide Hanawa, Chise Sugita, Yoshiaki Kikkawa, Tetsuya Yamada, Sachiko Wakai\",\"doi\":\"10.1111/1744-9987.14067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study elucidates factors affecting the severity and mortality in pre-Omicron and Omicron strains of SARS-CoV-2 and vaccination impact.</p><p><strong>Methods: </strong>This single-center retrospective observational study included 1598 hospitalized COVID-19 patients. Patients were grouped into \\\"pre-Omicron\\\" and \\\"Omicron\\\" periods. The endpoint was severe COVID-19 (oxygen saturation [SpO<sub>2</sub> ] < 94%). Logistic regression examined associations between clinical factors, including hemodialysis (HD), and the endpoint.</p><p><strong>Results: </strong>The HD patient mortality rate dropped from 16% pre-Omicron to 4% during the Omicron epidemic. HD was significantly associated with the study endpoint in both epidemics. Unvaccinated patients had a greater risk of reaching the study endpoint among patients receiving HD.</p><p><strong>Conclusion: </strong>These findings suggest that the Omicron variant, alongside vaccination and healthcare innovations, led to improved prognoses for HD patients with COVID-19. However, HD patients remain at a greater risk for severe COVID-19. Increased vaccination rates and optimized healthcare resources can improve this vulnerable population's prognoses.</p>\",\"PeriodicalId\":23021,\"journal\":{\"name\":\"Therapeutic Apheresis and Dialysis\",\"volume\":\" \",\"pages\":\"51-60\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Apheresis and Dialysis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/1744-9987.14067\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/9/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Apheresis and Dialysis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/1744-9987.14067","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Comparative outcomes of hemodialysis patients facing pre-Omicron and Omicron COVID-19 epidemics.
Introduction: This study elucidates factors affecting the severity and mortality in pre-Omicron and Omicron strains of SARS-CoV-2 and vaccination impact.
Methods: This single-center retrospective observational study included 1598 hospitalized COVID-19 patients. Patients were grouped into "pre-Omicron" and "Omicron" periods. The endpoint was severe COVID-19 (oxygen saturation [SpO2 ] < 94%). Logistic regression examined associations between clinical factors, including hemodialysis (HD), and the endpoint.
Results: The HD patient mortality rate dropped from 16% pre-Omicron to 4% during the Omicron epidemic. HD was significantly associated with the study endpoint in both epidemics. Unvaccinated patients had a greater risk of reaching the study endpoint among patients receiving HD.
Conclusion: These findings suggest that the Omicron variant, alongside vaccination and healthcare innovations, led to improved prognoses for HD patients with COVID-19. However, HD patients remain at a greater risk for severe COVID-19. Increased vaccination rates and optimized healthcare resources can improve this vulnerable population's prognoses.
期刊介绍：
Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
