两只老年北极熊阿尔茨海默病样病理的半定量评估。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Katherine L Lucot, Syed A Bukhari, Ebony D Webber, T Adam Bonham, Corinna Darian-Smith, Thomas J Montine, Sherril L Green
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引用次数: 0

摘要

与年龄相关的神经退行性改变,包括淀粉样β (Aβ)斑块、神经原纤维缠结(nft)和淀粉样血管病,与人类阿尔茨海默病(AD)患者的大脑相似,已在老年熊的大脑中报道。然而,由于评估认知障碍的困难和缺乏半定量评估Aβ斑块和nft的标准化方法,这些发现在熊中的意义尚不清楚。在这项研究中,我们使用美国国家老年痴呆症协会(NIA-AA)阿尔茨海默病(AD)神经病理学评估共识指南,评估了2只老年北极熊(28岁和37岁)档案脑组织的神经病理学变化。两只熊的Aβ (A)评分为3分,Braak分期(B)评分为3分,神经斑块(C)评分为3分。这些发现与阿尔茨海默病患者大脑中观察到的神经退行性改变是一致的。NIA-AA共识指南的应用,应用于本报告中对老年熊的神经病理学评估,证明了标准化半定量评估系统在脆弱野生动物物种衰老的比较和转化研究中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Semi-quantitative Assessment of Alzheimer's-like Pathology in Two Aged Polar Bears (<i>Ursus maritimus</i>).

Semi-quantitative Assessment of Alzheimer's-like Pathology in Two Aged Polar Bears (<i>Ursus maritimus</i>).

Semi-quantitative Assessment of Alzheimer's-like Pathology in Two Aged Polar Bears (Ursus maritimus).

Age-associated neurodegenerative changes, including amyloid β (Aβ) plaques, neurofibrillary tangles (NFTs), and amyloid angiopathy comparable to those seen in the brains of human patients with Alzheimer's disease (AD), have been reported in the brains of aged bears. However, the significance of these findings in bears is unclear due to the difficulty in assessing cognitive impairment and the lack of standardized approaches for the semiquantitative evaluation of Aβ plaques and NFTs. In this study, we evaluate the neuropathologic changes in archival brain tissue of 2 aged polar bears (Ursus maritimus, ages 28 and 37) using the National Institute of Aging-Alzheimer Association (NIA-AA) consensus guidelines for the neuropathologic assessment of Alzheimer's Disease (AD). Both bears had an Aβ (A) score of 3 of 3, Braak stage (B score) of 2 of 3, and neuritic plaque (C) score of 3 of 3. These findings are consistent with the neurodegenerative changes observed in brains of patients with AD. The application of NIA-AA consensus guidelines, as applied to the neuropathologic assessment of the aged bears in this report, demonstrates the use of standardized semiquantitative assessment systems for comparative, translational studies of aging in a vulnerable wildlife species.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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