利用细胞穿透肽的选择性和靶向药物/基因传递系统的最新进展

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL
So Hee Nam, Joonhyuck Park, Heebeom Koo
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引用次数: 15

摘要

生物细胞膜是活细胞的天然屏障。在过去的几十年里,细胞膜一直是生物活性和治疗药物有效输送的主要障碍。为了提高这些药物的疗效,已经考虑了额外的介质。细胞穿透肽(CPPs)是一系列主要由疏水和/或带正电的侧链组成的寡肽,可以增加与细胞膜的相互作用。基于cpp的递送平台在有效和直接递送各种货物(包括基因、蛋白质和小分子药物)方面显示出巨大的潜力。绕过内吞作用使基于cpp的递送系统比其他药物递送系统更能抵抗基于蛋白质的药物的降解。然而,CPPs的递送表现出本质上的非特异性靶向性,这限制了它们的医学应用。为了使CPPs具有特异性靶向能力,已经报道了ph敏感、酶特异性可切割和多靶向配体的偶联。对于不同大小和表面电荷的药物,仍需对CPPs的长度和序列进行优化。在临床使用之前,应仔细解决基于cpp的给药系统的毒性问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

Biological cell membranes are a natural barrier for living cells. In the last few decades, the cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic agents. To increase the drug efficacy of these agents, additional mediators have been considered. Cell-penetrating peptides (CPPs), a series of oligopeptides composed of mostly hydrophobic and/or positively charged side chains, can increase the interaction with the cell membrane. CPP-based delivery platforms have shown great potential for the efficient and direct cytosol delivery of various cargos, including genes, proteins, and small molecule drugs. Bypassing endocytosis allows the CPP-based delivery systems greater defense against the degradation of protein-based drugs than other drug delivery systems. However, the delivery of CPPs exhibits intrinsically non-specific targeting, which limits their medical applications. To endow CPPs with specific targeting ability, the conjugation of pH-sensitive, enzyme-specific cleavable, and multiple targeting ligands has been reported. Optimization of the length and sequence of CPPs is still needed for various drugs of different sizes and surface charges. Toxicity issues in CPP-based delivery systems should be addressed carefully before clinical use.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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