癌症的DNA甲基化:饮食和生活方式因素的表观遗传学。

IF 3.2 Q2 GENETICS & HEREDITY
Epigenetics Insights Pub Date : 2023-09-15 eCollection Date: 2023-01-01 DOI:10.1177/25168657231199893
Mohsen Maleknia, Nooshin Ahmadirad, Fereshteh Golab, Yasmina Katebi, Arsh Haj Mohamad Ebrahim Ketabforoush
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引用次数: 0

摘要

背景:DNA甲基化的改变在癌症的发展和进展中起着重要作用。饮食营养和生活方式行为可以影响DNA甲基化模式,从而调节癌症风险。引言:全面综述饮食和生活方式因素如何通过表观遗传学机制影响DNA甲基化并促进致癌作用的现有证据。材料和方法:使用PubMed进行文献检索,以确定2005年至2022年间发表的相关研究,这些研究检查了癌症中饮食/生活方式因素与DNA甲基化之间的关系。研究了饮食成分(如微量营养素、植物化学物质)、体育活动、吸烟和肥胖对动物和人类癌症模型中全球和基因特异性DNA甲基化变化的影响。提取了特定饮食/生活方式暴露、癌症类型、DNA甲基化靶点和潜在机制的数据。结果:发现多种饮食和生活方式因素通过影响DNA甲基转移酶活性、甲基供体的可用性和氧化应激的产生来影响DNA甲基化模式。调节细胞增殖、凋亡和炎症的特定基因甲基化的改变与癌症的发展和进展有关。结论:旨在调节DNA甲基化的饮食和生活方式干预具有通过表观遗传学机制预防和治疗癌症的潜力。需要进一步的研究来确定基于营养和生活方式的表观遗传学疗法的可操作目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors.

DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors.

DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors.

DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors.

Background: Alterations in DNA methylation play an important role in cancer development and progression. Dietary nutrients and lifestyle behaviors can influence DNA methylation patterns and thereby modulate cancer risk.

Introduction: To comprehensively review available evidence on how dietary and lifestyle factors impact DNA methylation and contribute to carcinogenesis through epigenetic mechanisms.

Materials and methods: A literature search was conducted using PubMed to identify relevant studies published between 2005 and 2022 that examined relationships between dietary/lifestyle factors and DNA methylation in cancer. Studies investigating the effects of dietary components (eg, micronutrients, phytochemicals), physical activity, smoking, and obesity on global and gene-specific DNA methylation changes in animal and human cancer models were included. Data on specific dietary/lifestyle exposures, cancer types, DNA methylation targets and underlying mechanisms were extracted.

Results: Multiple dietary and lifestyle factors were found to influence DNA methylation patterns through effects on DNA methyltransferase activity, methyl donor availability, and generation of oxidative stress. Altered methylation of specific genes regulating cell proliferation, apoptosis, and inflammation were linked to cancer development and progression.

Conclusion: Dietary and lifestyle interventions aimed at modulating DNA methylation have potential for both cancer prevention and treatment through epigenetic mechanisms. Further research is needed to identify actionable targets for nutrition and lifestyle-based epigenetic therapies.

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Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
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