白细胞介素23在系统性狼疮患者中的意义:与疾病活动性和损伤指标的关系。

IF 5.3 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Maysa M Haroon, Gehan A Hegazy, Mohammed A Hassanien, Olfat Shaker, Wafaa H Hussein
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引用次数: 0

摘要

背景:细胞和体液免疫反应的失调是系统性红斑狼疮(SLE)发病机制的核心。促炎细胞因子,如白细胞介素23 (il - 23)及其在促进这种失调中的作用最近得到了高度重视。本研究比较了85名埃及SLE患者和85名健康对照者的血清il - 23水平。然后,il - 23水平与SLE各种疾病参数、疾病活动性和损害指标相关。结果:与健康个体相比,SLE患者血清il - 23水平显著升高。此外,il - 23水平与SLE疾病活动性指数(SLEDAI)呈正相关,与关节炎、癫痫发作、补体(C3、C4)消耗以及肾炎参数(血尿、脓尿、尿型和蛋白尿)呈正相关。il - 23水平与口服强的松龙剂量呈正相关。结论:SLE患者血清中il - 23水平较高,且与疾病活动度,尤其是狼疮性肾炎相关。其在SLE发病机制中的确切作用以及是否可作为潜在的SLE生物标志物或治疗靶点有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Significance of Interleukin 23 in Systemic Lupus Patients: Relation to Disease Activity and Damage Indices.

Background: Dysregulation of both cellular and humoral immune responses is central in systemic lupus erythematosus (SLE) pathogenetic mechanisms. Proinflammatory cytokines, such as interleukin 23 (IL23), and their roles in promoting such dysregulation have recently been highly considered. This research compared IL23 serum levels in 85 Egyptian SLE patients and 85 healthy controls. Then, IL23 level was correlated to various SLE disease parameters, disease activity, and damage indices.

Results: IL23 serum levels were significantly elevated in SLE patients versus healthy individuals. Furthermore, IL23 levels were positively correlated with SLE disease activity index (SLEDAI) and were positively correlated with arthritis, seizures, consumption of complements (C3, C4), and with parameters of nephritis (hematuria, pyuria, casts, and proteinuria). A positive correlation was also found between IL23 levels and oral prednisolone dose.

Conclusion: IL23 has higher levels in the serum of SLE patients, and is correlated to activity of the disease, especially lupus nephritis. Further researchis needed to explore its exact role in SLE pathogenesis and whether it can be considered a potential biomarker or therapeutic target in SLE.

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来源期刊
Biologics : Targets & Therapy
Biologics : Targets & Therapy MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
8.30
自引率
0.00%
发文量
22
审稿时长
16 weeks
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