COVID-19感染哮喘和吸烟患者重症监护与管理

IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Dongming Lu, Obaid Yaqoob, Manish Kumar, Ajay Singh Kushwah, Rahul Kumar Sharma, Devinder Kumar, Yogendra Mavai, Rukaiya Khan
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引用次数: 0

摘要

本世纪最严重的灾难COVID-19被称为“有史以来最危及生命的灾难”。哮喘患者更容易受到COVID-19与潜在炎症的复杂相互作用的影响。为了保护自己免受COVID-19的侵害,哮喘患者在使用治疗技术和药物(例如支气管扩张剂、5-脂氧合酶抑制剂)时必须非常警惕,这些技术和药物可能用于治疗轻度、中度和重度COVID-19适应症。哮喘患者可能有更严重的COVID-19症状,这可能导致病情恶化。在COVID-19急性患者的支气管中发现了几种细胞因子升高,这表明这种疾病可能通过增加炎症来加重哮喘发作。在t细胞水平较高的哮喘患者中,COVID-19症状的强度会减轻。一些抗生素、抗病毒药物、解热药和抗炎药已被建议用于抑制哮喘患者的COVID-19症状。此外,吸烟者更有可能加重COVID-19感染的后果。由于COVID-19而住院接受重症监护,需要机械呼吸,并遭受严重的健康影响,这些都是以前吸烟的人可能出现的结果。吸烟会损害气道和肺泡,这大大增加了与covid -19相关的健康并发症的风险。既往有吸烟记录的患者易出现严重的COVID-19疾病症状,基本上需要联合使用支气管扩张剂、黏液解药、抗病毒药物和抗毒蕈碱药物来应对这种情况。现就哮喘和吸烟患者新冠肺炎感染的护理与管理进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intensive critical care and management of asthmatic and smoker patients in COVID-19 infection.

This century's most serious catastrophe, COVID-19, has been dubbed "the most life-threatening disaster ever". Asthmatic persons are even more prone to COVID-19's complex interplay with the underlying inflammatory condition. In order to protect themselves against COVID-19, asthmatic patients must be very vigilant in their usage of therapeutic techniques and drugs (e.g., bronchodilators, 5-lipoxygenase inhibitors), which may be accessed to deal with mild, moderate, and severe COVID-19 indications. People with asthma may have more severe COVID-19 symptoms, which may lead to a worsening of their condition. Several cytokines were found to be elevated in the bronchial tracts of patients with acute instances of COVID-19, suggesting that this ailment may aggravate asthma episodes by increasing inflammation. The intensity of COVID-19 symptoms is lessened in patients with asthma who have superior levels of T-cells. Several antibiotics, antivirals, antipyretics, and anti-inflammatory drugs have been suggested to suppress COVID-19 symptoms in asthmatic persons. Furthermore, smokers are more likely to have aggravated repercussions in COVID-19 infection. Being hospitalized to critical care due to COVID-19, needing mechanical breathing, and suffering from serious health repercussions, are all possible outcomes for someone who has previously smoked. Smoking damages airways and alveoli, which significantly raises the risk of COVID-19-related health complications. Patients with a previous record of smoking are predisposed to severe COVID-19 disease symptoms that essentially require a combination of bronchodilators, mucolytics, antivirals, and antimuscarinic drugs, to cope with the situation. The present review discusses the care and management of asthmatic and smoker patients in COVID-19 infection.

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来源期刊
Acta Pharmaceutica
Acta Pharmaceutica PHARMACOLOGY & PHARMACY-
CiteScore
5.20
自引率
3.60%
发文量
20
审稿时长
>12 weeks
期刊介绍: AP is an international, multidisciplinary journal devoted to pharmaceutical and allied sciences and contains articles predominantly on core biomedical and health subjects. The aim of AP is to increase the impact of pharmaceutical research in academia, industry and laboratories. With strong emphasis on quality and originality, AP publishes reports from the discovery of a drug up to clinical practice. Topics covered are: analytics, biochemistry, biopharmaceutics, biotechnology, cell biology, cell cultures, clinical pharmacy, drug design, drug delivery, drug disposition, drug stability, gene technology, medicine (including diagnostics and therapy), medicinal chemistry, metabolism, molecular modeling, pharmacology (clinical and animal), peptide and protein chemistry, pharmacognosy, pharmacoepidemiology, pharmacoeconomics, pharmacodynamics and pharmacokinetics, protein design, radiopharmaceuticals, and toxicology.
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