Achyut Dahal, Jafrin Jobayer Sonju, Konstantin G Kousoulas, Seetharama D Jois
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引用次数: 0
摘要
严重急性呼吸系统综合征冠状病毒-2（SARS-CoV-2）Covid-19大流行在全球范围内造成了很高的发病率和死亡率。可采用多种策略阻止病毒进入细胞，包括抑制病毒尖峰糖蛋白与细胞受体之间的蛋白-蛋白相互作用（PPIs），以及阻止尖峰蛋白构象变化（裂解/活化和融合所需的构象变化）。尖峰蛋白介导的病毒附着和通过病毒包膜与细胞膜融合进入细胞的过程涉及由表现出特殊二级结构的短肽片段介导的 PPI。因此，能够抑制这些 PPIs 的多肽可用作潜在的抗病毒药物，防止病毒进入和传播。这篇综述主要介绍了作为 PPI 调节剂和蛋白酶抑制剂的肽类和拟肽类药物对 SARS-CoV-2 的作用。
Peptides and peptidomimetics as therapeutic agents for Covid-19.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Covid-19 pandemic has caused high morbidity and mortality rates worldwide. Virus entry into cells can be blocked using several strategies, including inhibition of protein-protein interactions (PPIs) between the viral spike glycoprotein and cellular receptors, as well as blocking of spike protein conformational changes that are required for cleavage/activation and fusogenicity. The spike-mediated viral attachment and entry into cells via fusion of the viral envelope with cellular membranes involve PPIs mediated by short peptide fragments exhibiting particular secondary structures. Thus, peptides that can inhibit these PPIs may be used as potential antiviral agents preventing virus entry and spread. This review is focused on peptides and peptidomimetics as PPI modulators and protease inhibitors against SARS-CoV-2.
Peptide ScienceBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
5.20
自引率
4.20%
发文量
36
期刊介绍：
The aim of Peptide Science is to publish significant original research papers and up-to-date reviews covering the entire field of peptide research. Peptide Science provides a forum for papers exploring all aspects of peptide synthesis, materials, structure and bioactivity, including the use of peptides in exploring protein functions and protein-protein interactions. By incorporating both experimental and theoretical studies across the whole spectrum of peptide science, the journal serves the interdisciplinary biochemical, biomaterials, biophysical and biomedical research communities.
Peptide Science is the official journal of the American Peptide Society.
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