抗体介导的排斥反应的组织学和分子特征。

IF 1.8 4区 医学 Q3 TRANSPLANTATION
Ivy A Rosales, Rex Neal Smith, Robert B Colvin
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引用次数: 1

摘要

综述目的:本综述旨在总结近年来同种异体肾移植的病理学和分子分析研究的亮点。最近的发现:随着抗体介导的排斥反应(AMR)研究的不断发展,研究的重点是通过转录本研究识别参与AMR发展的致病途径,以及通过将Banff病理病变与临床和分子数据相关联或通过机器学习来改进诊断方法。值得注意的是,过去一年的研究产生了高影响力,强调了病理和分子相关性的重要性,以及有助于预测的转录物或基因集的检测。涉及完善病理标准的研究也强调了为实现诊断准确性和标准化所做的持续努力。综述:涉及定义AMR的组织学和分子特征的研究是识别和理解发病途径的核心,在制定诊断标准方面仍然至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histologic and molecular features of antibody-mediated rejection.

Purpose of review: This review aims to summarize the highlights from recent research that involved pathological and molecular analysis of kidney allografts.

Recent findings: As the research on antibody-mediated rejection (AMR) continues to evolve, studies are focused on identification through transcript studies of pathogenetic pathways involved in the development of AMR as well as refinement of diagnostic methods either by correlating Banff pathologic lesions with clinical and molecular data or by machine learning. Of note, the past year has generated high impact research that underscore the importance of pathologic and molecular correlations and detection of transcripts or gene sets that would aid prognostication. The studies involving refinement of pathologic criteria also highlight the continuous efforts to achieve diagnostic accuracy and standardization.

Summary: Research involving histologic and molecular characteristics that define AMR are central to identification and understanding of pathogenetic pathways and remain critical in the development of diagnostic criteria.

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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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