约旦的切尔克斯人和车臣人:十年流行病学和遗传学研究成果。

IF 1.5 Q4 GENETICS & HEREDITY
Journal of Community Genetics Pub Date : 2023-12-01 Epub Date: 2023-09-13 DOI:10.1007/s12687-023-00668-6
Sara Abudahab, Nancy Hakooz, Laith Al-Etian, Kawkab Shishani, Adel Bashqawi, John Connolly, Joseph T Glessner, Hui-Qi Qu, Jingchun Qu, Hakon Hakonarson, Rana Dajani
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引用次数: 0

摘要

约旦的切尔克斯人和车臣人都有高加索人的血统,但由于同族通婚率很高,他们在遗传学上是孤立的。近来,人们对这些人群的兴趣导致了对他们在遗传方面的相似性、差异性以及各种疾病的流行病学差异的研究。研究探索了他们对糖尿病、高血压和癌症等疾病的易感性。此外,药物遗传学(PGx)研究也对这些人群的药物反应差异进行了调查,而法医研究则进一步促进了对这些人群的了解。在这篇综述文章中,我们首先讨论了这些少数群体的背景。然后,我们展示了对生活在约旦的切尔克斯人和车臣人的遗传关系进行原理成分分析(PCA)的结果。在此,我们总结了 10 年来对他们的研究成果。这篇综述文章对研究成果进行了全面总结,这些研究成果对于了解生活在约旦的切尔克斯人和车臣人的独特遗传特征、疾病发病率和用药反应具有真正的价值。我们相信,深入了解各种疾病的根本原因,并开发出有益于整个社会的有效治疗方法,是让广大族群参与基因研究的当务之急。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Circassians and the Chechens in Jordan: results of a decade of epidemiological and genetic studies.

Circassians and Chechens in Jordan, both with Caucasian ancestry, are genetically isolated due to high rate of endogamous marriages. Recent interest in these populations has led to studies on their genetic similarities, differences, and epidemiological differences in various diseases. Research has explored their predisposition to conditions like diabetes, hypertension, and cancer. Moreover, pharmacogenetic (PGx) studies have also investigated medication response variations within these populations, and forensic studies have further contributed to understanding these populations. In this review article, we first discuss the background of these minority groups. We then show the results of a principle component analysis (PCA) to investigate the genetic relationships between Circassian and Chechen populations living in Jordan. We here present a summary of the findings from the 10 years of research conducted on them. The review article provides a comprehensive summary of research findings that are truly valuable for understanding the unique genetic characteristics, diseases' prevalence, and medication responses among Circassians and Chechens living in Jordan. We believe that gaining deeper comprehension of the root causes of various diseases and developing effective treatment methods that benefit the society as a whole are imperative to engaging a wide range of ethnic groups in genetic research.

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来源期刊
Journal of Community Genetics
Journal of Community Genetics GENETICS & HEREDITY-
CiteScore
3.30
自引率
5.30%
发文量
54
期刊介绍: The Journal of Community Genetics is an international forum for research in the ever-expanding field of community genetics, the art and science of applying medical genetics to human communities for the benefit of their individuals. Community genetics comprises all activities which identify persons at increased genetic risk and has an interest in assessing this risk, in order to enable those at risk to make informed decisions. Community genetics services thus encompass such activities as genetic screening, registration of genetic conditions in the population, routine preconceptional and prenatal genetic consultations, public education on genetic issues, and public debate on related ethical issues. The Journal of Community Genetics has a multidisciplinary scope. It covers medical genetics, epidemiology, genetics in primary care, public health aspects of genetics, and ethical, legal, social and economic issues. Its intention is to serve as a forum for community genetics worldwide, with a focus on low- and middle-income countries. The journal features original research papers, reviews, short communications, program reports, news, and correspondence. Program reports describe illustrative projects in the field of community genetics, e.g., design and progress of an educational program or the protocol and achievement of a gene bank. Case reports describing individual patients are not accepted.
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