Circ_0001060上调并促进骨肉瘤的进展

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

DNA and cell biology Pub Date : 2023-01-01 DOI:10.1089/dna.2022.0500

Huijiang Liu, Qian Huang, Haijun Tang, Kai Luo, Yiwu Qin, Feicui Li, Fuxing Tang, Jiqing Zheng, Wenyu Feng, Boxiang Li, Tianyu Xie, Yun Liu

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引用次数: 1

摘要

环状RNA (circRNA)参与多种癌症的发生和发展。迄今为止，circRNA在骨肉瘤(OS)中的表达和机制尚不清楚。我们之前发现circ_0001060在OS肿瘤组织中高表达。在这项工作中，我们发现circ_0001060的高水平表达与OS患者的临床分期晚、肿瘤体积大、转移频率高、预后差显著相关。此外，我们证实沉默circ_0001060抑制了OS细胞的增殖和迁移。通过生物信息学分析，我们构建了三个circRNA-miRNA-mRNA调控模块(circ_0001060- mir -203a-5p- trim21、circ_0001060- mir -208b-5p- map3k5和circ_0001060- mir -203a-5p- prkx)，提示这些信号轴可能参与了circ_0001060对OS的抑制作用。综上所述，circ_0001060是一种新的肿瘤生物标志物，也是一种潜在的治疗靶点。

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Circ_0001060 Upregulates and Encourages Progression in Osteosarcoma.

Circular RNA (circRNA) is involved in the occurrence and development of various cancers. To this day, the expression and mechanism of circRNA in osteosarcoma (OS) remain unclear. We previously found that circ_0001060 was highly expressed in OS tumor tissues. In this work, we identified that high level expression of circ_0001060 was significantly associated with late clinical stage, larger tumor volume, higher frequency of metastasis, and poor prognosis in OS patients. Furthermore, we confirmed that silencing circ_0001060 inhibited the proliferation and migration of OS cell. Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS. To sum up, circ_0001060 is a novel tumor biomarker for OS as well as a potential therapeutic target.

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来源期刊

DNA and cell biology 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.