血管调节因子作为手臂振动综合征早期生物标志物的研究。

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Occupational and Environmental Medicine Pub Date : 2023-12-01 Epub Date: 2023-09-01 DOI:10.1097/JOM.0000000000002957

Hongyu Yang, Ziyu Chen, Xiuwen Hu, Nuoyan Wei, Jiajie Li, Yuan Wei, Qingsong Chen

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引用次数: 0

摘要

目的:研究振动暴露后和振动诱发白指(VWF)发病过程中血管调节因子的表达变化，筛选可作为HAVS早期生物标志物的血管调节因子。方法:采用中国某工厂的判断抽样方法，选取有VWF和手传振动暴露但无VWF的工人进行研究。从所有受试者身上采集血液样本，用ELISA法测定9种血管调节因子的水平。结果:对9种血管调节剂进行受试者工作特征曲线分析，评价其对VWF的诊断敏感性，曲线下面积:PGI 2 = 0.861, ANP = 0.840。结论:总的来说，PGI 2和ANP在HAVS的早期诊断中最有潜力。

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A Study on Vascular Regulators as Early Biomarkers of Hand Arm Vibration Syndrome.

Objectives: Purposes of this study are to study the changes in expression of vascular regulators after vibration exposure and during the onset of vibration-induced white finger (VWF) and to screen for vascular regulatory factors that could be used as early biomarkers of HAVS.

Methods: Using judgmental sampling from a Chinese factory, workers with VWF and hand-transmitted vibration exposure but without VWF were selected for research. Blood samples were taken from all subjects, and the levels of nine of the vascular regulators were measured using ELISA.

Results: Receiver operating characteristic curve analysis was performed on nine vascular regulators to assess their diagnostic sensitivity for VWF with the following area under the curve results: PGI 2 = 0.861, ANP = 0.840.

Conclusions: Collectively, PGI 2 and ANP exhibited the most potential for the early diagnosis of HAVS.

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来源期刊

Journal of Occupational and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

9.40%

发文量

402

审稿时长

3-8 weeks

期刊介绍： Journal of Occupational and Environmental Medicine is an indispensable guide to good health in the workplace for physicians, nurses, and researchers alike. In-depth, clinically oriented research articles and technical reports keep occupational and environmental medicine specialists up-to-date on new medical developments in the prevention, diagnosis, and rehabilitation of environmentally induced conditions and work-related injuries and illnesses.