影响阿尔茨海默病患者经颅直流电刺激的结果和因素:一项系统综述。

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Rabeet Tariq, Bhavya Kansal, Rameen Shaikh, Shria Datta, Harsh Anadkat, Seema Bista
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引用次数: 2

摘要

简介:阿尔茨海默病(AD)是最常见的痴呆症。已经提出了各种药物和非药物治疗方法来预防AD患者的认知能力下降。经颅直流电刺激(tDCS)是一种用于增强大脑认知功能和运动技能的神经调节技术。我们的研究旨在评估tDCS对AD患者的影响,包括对一般认知状态、记忆、注意力、执行功能、语言、智商和神经心理的影响,以及影响结果的因素。方法:系统检索PubMed、ScienceDirect和Cochrane Library数据库中(经颅直流电刺激)和(阿尔茨海默氏症)的相关证据。删除重复的文章,对使用tDCS诊断为AD的患者进行双盲、安慰剂对照、随机临床试验(III期)、病例研究和病例系列筛选。对文章全文进行评估,并对研究进行选择和分析以纳入综述。结果:总共回顾了20项研究。AtDCS后认知状态、执行功能、工作记忆、识别记忆和语言功能的改善取决于刺激极性和刺激区域。tDCS对注意力、联想记忆、回忆记忆、视觉空间能力和神经精神症状没有显著影响。讨论:分析治疗结果和可能影响治疗结果的因素,包括治疗次数、电流密度、刺激极性(阴极/阳极/双极性)、刺激区域、训练和研究时间。结论:tDCS是一种耐受性良好的治疗方法,可用于改善阿尔茨海默病患者的几个认知领域。其治疗结果受极性(阴极/阳极)、刺激地点、治疗次数和研究期间的任何训练的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcomes and Factors Affecting Transcranial Direct Current Stimulation in Alzheimer's Disease Patients: A Systematic Review.

Introduction: Alzheimer's disease (AD) is the most common form of dementia. There have been various proposed pharmacologic and non-pharmacologic treatments proposed for preventing cognitive decline in AD patients. Transcranial Direct Current Stimulation (tDCS) is a neuromodulation technique used to enhance cognitive functions and motor skills of the brain. Our study aimed to assess the effects of tDCS in AD patients, including effects on general cognitive status, memory, attention, executive functions, language, IQ, and neuropsychological effects, along with the factors influencing the outcomes.

Methods: Systematic searches were conducted for relevant evidence using PubMed, ScienceDirect, and Cochrane Library databases for (Transcranial Direct Current Stimulation) and (Alzheimer's). Duplicates were removed, and the remaining articles were screened for double-blind, placebo-controlled, randomized clinical trials (Phase III), case studies, and case series on patients diagnosed with AD using tDCS. The articles were assessed for full text, and studies were selected and analyzed to include in the review.

Results: Overall, 20 studies were reviewed. Cognitive status, executive function and working memory, recognition memory, and language function may improve following AtDCS depending on the stimulation polarity and area stimulated. No significant effects of tDCS were seen on attention, associative memory, recall memory, visuospatial ability, and neuropsychiatric symptoms.

Discussion: Therapy outcomes and the factors that could affect them were analyzed, which included the number of sessions taken, current density, stimulation polarity (cathodal/anodal/dual), area stimulated, training(s) given, and study timeline.

Conclusion: tDCS is a well-tolerated therapy that can be used for improving several cognitive domains in patients having Alzheimer's disease. Its treatment outcomes are affected by polarity (cathodal/ anodal), site of stimulation, number of sessions taken, and any training(s) given during the study.

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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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