产前多不饱和脂肪酸与波兰母婴队列研究中儿童特应性皮炎和食物过敏

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2023-09-07 Epub Date: 2023-08-28 DOI:10.13075/ijomeh.1896.02222
Alexandra Jerzyńska, Alicja Polańska, Elżbieta Trafalska, Agnieszka Jankowska, Daniela Podlecka, Agnieszka Brzozowska
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引用次数: 0

摘要

目的:多不饱和脂肪酸(PUFAs)参与免疫系统调节和炎症。这项前瞻性研究的目的是评估怀孕期间母亲饮食中PUFAs摄入量与7-9岁以下儿童特应性皮炎(AD)和食物过敏(FA)之间的关系。材料和方法:研究人群包括来自波兰母亲和儿童队列(rep_pl)的557对母子。根据怀孕20-24周期间完成的食物频率问卷,使用食物成分表估算n-3和n-6 PUFAs以及n-6:n-3脂肪酸比例。儿童在1岁、2岁和7-9岁时由过敏症专科医生进行健康检查。采用广义估计方程来评估AD和FA在3个时间点的患病率。方程的自变量为n-3、n-6 PUFAs和n-6:n-3 PUFAs比值。此外,采用多变量模型评估PUFAs与AD和FA的关系。结果:1岁、2岁和7-9岁AD患病率分别为37%、26%和21%,FA患病率分别为26%、22%和22%。较高的n-6:n-3脂肪酸比值与7-9岁AD患病率相关(p < 0.07)。在多变量模型中,n-6 PUFAs与持续性FA风险增加显著相关(OR = 1.5, 95% CI: 1.1-2.1)。结论:这些结果可能有助于现有的关于孕期母亲饮食对儿童最佳健康影响的知识,但在得出结论和制定临床实践指南之前,还需要进一步的研究。中华医学杂志,2009;33(3):428- 436。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prenatal polyunsaturated fatty acids and atopic dermatitis and food allergy in children from Polish Mother and Child Cohort study.

Objectives: Polyunsaturated fatty acids (PUFAs) are involved both in immune system regulation and inflammation. The aim of this prospective study was to evaluate the association between maternal dietary intake of PUFAs during pregnancy and atopic dermatitis (AD) and food allergy (FA) in their children up to 7-9 years of age.

Material and methods: The study population consists of 557 mother-child pairs from the Polish Mother and Child Cohort (REPRO_PL). Based on the Food Frequency Questionnaire completed between the 20-24th weeks of pregnancy, n-3 and n-6 PUFAs as well as n-6:n-3 fatty acid ratio were estimated using food composition tables. Children's health examinations at the age of 1, 2, and 7-9 years were performed by an allergist. Generalized estimating equations were performed in order to assess the prevalence of AD and FA at 3 time points. Independent variables in the equation were n-3, n-6 PUFAs and n-6:n-3 PUFAs ratio. In addition multivariate models were performed to assess the association of PUFAs with AD and FA.

Results: The prevalence of AD was 37%, 26% and 21% and FA 26%, 22% and 22% at age of 1, 2 and 7-9 years, respectively. Higher n-6:n-3 fatty acid ratio correlated with higher prevalence of AD at age of 7-9 years (p < 0.07). In multivariate model n-6 PUFAs were significantly associated with increased risk of persistent FA (OR = 1.5, 95% CI: 1.1-2.1).

Conclusions: These results may contribute to the existing knowledge on the impact of maternal diet during pregnancy on children's optimal health, however further studies are needed before drawing conclusions and creating clinical practice guidelines. Int J Occup Med Environ Health. 2023;36(3):428-36.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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