Ravi Thakker, Krishna Suthar, Pooja Bhakta, Marissa Lee, Deaa Abu Jazar, Milee Patel, Ayman Elbadawi, Aiham Albaeni, Syed Mustajab Hasan, Mohammed Faluk, Maurice Willis, Khaled Chatila, Wissam Khalife, Umamahesh Rangasetty, Afaq Motiwala, Syed Gilani, Hani Jneid
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Secondary outcomes included cardiac mortality, myocardial infarction (MI), and restenosis.</p><p><strong>Results: </strong>The analysis included four observational studies with a total of 13,941 patients for the primary outcome of all-cause mortality. There were a total of 1,322 patients analyzed for cardiac mortality, 13,103 for MI, and 10,530 for restenosis. The longest follow-up for the primary outcome was 16 years. There was statistically significant higher risk of all-cause mortality in patients who underwent thoracic radiation (risk ratio (RR): 1.29, 95% confidence interval (CI): 1.08 - 1.54, P = 0.004). There was no statistically significant difference in cardiac mortality (RR: 1.15, 95% CI: 0.83 - 1.61, P = 0.40), MI (RR: 1.01, 95% CI: 0.20 - 5.08, P = 0.99), and restenosis (RR: 1.92, 95% CI: 0.24 - 15.35, P = 0.54).</p><p><strong>Conclusion: </strong>In this meta-analysis, we found a higher risk of all-cause mortality in patients with a history of thoracic radiation undergoing PCI, likely from underlying malignancy itself.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"13 6","pages":"333-338"},"PeriodicalIF":1.4000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/c9/cr-13-333.PMC9822675.pdf","citationCount":"1","resultStr":"{\"title\":\"Percutaneous Coronary Intervention Outcomes in Patients With Prior Thoracic Radiation Therapy: A Systematic Review and Meta-Analysis.\",\"authors\":\"Ravi Thakker, Krishna Suthar, Pooja Bhakta, Marissa Lee, Deaa Abu Jazar, Milee Patel, Ayman Elbadawi, Aiham Albaeni, Syed Mustajab Hasan, Mohammed Faluk, Maurice Willis, Khaled Chatila, Wissam Khalife, Umamahesh Rangasetty, Afaq Motiwala, Syed Gilani, Hani Jneid\",\"doi\":\"10.14740/cr1426\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Thoracic radiation predisposes patients to accelerated coronary artery disease. 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引用次数: 1
摘要
背景:胸部放射易使患者加速冠状动脉病变。对于接受胸部放射治疗的患者进行血运重建术后的短期和长期结果,目前缺乏相关数据。方法:我们对Medline、Cochrane和Scopus数据库进行了检索,以比较接受胸部放射治疗和经皮冠状动脉介入治疗(PCI)的癌症患者的结果。我们荟萃分析的主要结果是全因死亡率。次要结局包括心脏死亡率、心肌梗死(MI)和再狭窄。结果:该分析包括4项观察性研究,共13941例患者,主要结局为全因死亡率。共有1322例心脏死亡,13103例心肌梗死,10530例再狭窄。主要结果的最长随访时间为16年。接受胸部放射治疗的患者全因死亡风险较高(风险比(RR): 1.29, 95%可信区间(CI): 1.08 ~ 1.54, P = 0.004)。两组心脏死亡率(RR: 1.15, 95% CI: 0.83 ~ 1.61, P = 0.40)、心肌梗死(RR: 1.01, 95% CI: 0.20 ~ 5.08, P = 0.99)、再狭窄(RR: 1.92, 95% CI: 0.24 ~ 15.35, P = 0.54)差异无统计学意义。结论:在这项荟萃分析中,我们发现有胸部放射史的患者接受PCI的全因死亡率更高,可能来自潜在的恶性肿瘤本身。
Percutaneous Coronary Intervention Outcomes in Patients With Prior Thoracic Radiation Therapy: A Systematic Review and Meta-Analysis.
Background: Thoracic radiation predisposes patients to accelerated coronary artery disease. There is a paucity of data in both short-term and long-term outcomes following revascularization in patients who have undergone thoracic radiation.
Methods: We performed a search of the Medline, Cochrane, and Scopus databases for studies that compared outcomes in cancer patients who have undergone thoracic radiation and percutaneous coronary intervention (PCI). The primary outcome of our meta-analysis was all-cause mortality. Secondary outcomes included cardiac mortality, myocardial infarction (MI), and restenosis.
Results: The analysis included four observational studies with a total of 13,941 patients for the primary outcome of all-cause mortality. There were a total of 1,322 patients analyzed for cardiac mortality, 13,103 for MI, and 10,530 for restenosis. The longest follow-up for the primary outcome was 16 years. There was statistically significant higher risk of all-cause mortality in patients who underwent thoracic radiation (risk ratio (RR): 1.29, 95% confidence interval (CI): 1.08 - 1.54, P = 0.004). There was no statistically significant difference in cardiac mortality (RR: 1.15, 95% CI: 0.83 - 1.61, P = 0.40), MI (RR: 1.01, 95% CI: 0.20 - 5.08, P = 0.99), and restenosis (RR: 1.92, 95% CI: 0.24 - 15.35, P = 0.54).
Conclusion: In this meta-analysis, we found a higher risk of all-cause mortality in patients with a history of thoracic radiation undergoing PCI, likely from underlying malignancy itself.
期刊介绍:
Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.