由于宫内发育迟缓造成的身材矮小。临床和激素代谢特征,生长刺激疗法的可能性]。

Q4 Medicine
E V Nagaeva
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引用次数: 0

摘要

本文介绍了由于宫内发育迟缓而导致的身材矮小的数据。这种类型的身材矮小-单独的病种,联合出生时小于胎龄的儿童。他们中的大多数在生命的最初几年有加速的生长速度,使孩子的体重增长指标正常化,并赶上同龄人的发展。在没有加速生长速度的情况下,儿童在整个童年时期身体发育落后的风险很高,最终长势较低,成年后个子不高。此外,出生时体型小与许多激素和代谢特征有关,成年后有患代谢综合征的风险。据推测,缺乏出生后生长加速是由于GH-IGF1轴的各种损伤(部分GH缺乏,部分GH抵抗,部分IGF1抵抗)。在生命早期开始的生长激素治疗能够使儿童时期的生长速度正常化,并最终显著改善或使出生时小于胎龄的矮小儿童的最终生长正常。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Short stature due to intrauterine growth retardation. Clinical and hormonal-metabolic features, possibilities of growth-stimulating therapy].

The article presents data about short stature due to intrauterine development delay. This type of short stature - separate nosology, unites children born small for gestation age. The majority of them in the first years of life have accelerated growth rates, allowing the child to normalize their weight-growth indicators and catch up in the development of peers. In the absence of an accelerated growth rates, children have a high risk of lagging behind in physical development throughout childhood, achieving low final growth and becoming short adults. In addition, the fact of birth with small body sizes is associated with a number of hormonal and metabolic features, a risk of metabolic syndrome in adult years.It is assumed that the absence of postnatal growth acceleration is due to various damages to the GH-IGF1 axis (partial GH deficiency, partial resistance to GH, partial resistance to IGF1). Growth hormone therapy, initiated early in life, is able to normalize growth rates in childhood and ultimately significantly improve or normalize the final growth of short stature children born small for gestational age.

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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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