天然产品治疗放射性口腔黏膜炎的有效性:系统综述

Q3 Medicine
Zulfa Fidi Pranadwista , Nanan Nur'aeny
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引用次数: 0

摘要

放射性口腔粘膜炎(RIOM)是电离辐射和正常组织损伤引起的常见毒性反应之一,是放射治疗和化疗的并发症。放射治疗是治疗头颈癌症(HNC)的一种选择。使用天然产品是RIOM的一种替代疗法。这篇综述旨在描述天然产品(NBPs)在降低严重程度、疼痛评分、发病率、口腔病变大小和其他症状(如吞咽困难、构音障碍和吞咽困难)方面的有效性。本系统审查遵循系统审查和荟萃分析(PRISMA)指南的首选报告项目。Pubmed、ScienceDirect和Ebscohost CINAHL Plus数据库用于文章搜索。纳入标准是2012年至2022年发表的研究,全文可用英文,一项人类研究,以及一项随机临床试验(RCT),该试验评估NBP治疗诊断为HNC的RIOM患者的效果。本研究的人群是接受放射或化学治疗后出现口腔粘膜炎的HNC患者。NBP是麦卢卡蜂蜜、百里香蜂蜜、芦荟、金盏花、多花茶、车前草和姜黄。纳入的12篇文章中,有8篇在各种参数上对RIOM表现出显著的有效性,如严重程度、发病率、疼痛评分、口腔病变大小的降低,以及口腔粘膜炎的其他症状,如吞咽困难和灼口综合征。这篇综述的结论是NBPs治疗HNC患者的RIOM是有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness of natural-based products for radiation-induced oral mucositis therapy: A systematic review

Radiation-induced oral mucositis (RIOM) is one of the common toxic reactions from ionizing radiation and normal tissue injuries as a complication of radiation therapy and chemotherapy. Radiation therapy is an option for the treatment of head and neck cancer (HNC). The use of natural products is an alternative therapy for RIOM. This review aimed to describe the effectiveness of natural-based products (NBPs) in reducing the severity, pain score, incidence, oral lesion size, and other symptoms such as dysphagia, dysarthria, and odynophagia. This systematic review follows the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. Pubmed, ScienceDirect, and Ebscohost-CINAHL Plus databases were used for article searches. The inclusion criteria were studies published from 2012 to 2022 with full text available, in English, a study in humans, and a Randomized Clinical Trial (RCT) that evaluate the effect of NBPs therapy in RIOM patients diagnosed with HNC. This study's population was HNC patients who had oral mucositis after receiving radiation or chemical therapy. The NBPs were manuka honey, thyme honey, aloe vera, calendula, zataria multiflora, Plantago major L., and turmeric. Eight of the twelve included articles showed significant effectiveness against RIOM in various parameters, such as a decrease in severity, incidence rate, pain score, oral lesion size, and the other symptoms of oral mucositis such as dysphagia and burning mouth syndrome. This review concludes that NBPs therapy is effective for RIOM in HNC patients.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
148
审稿时长
56 days
期刊介绍: Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.
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