普瑞巴林抑制纤维肌痛综合征患者的促炎细胞因子释放。

IF 1.1 4区 医学 Q4 Medicine
Pınar Ellergezen, Alev Alp, Sinan Çavun, Melih Çelebi, Aslı Ceren Macunluoğlu
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引用次数: 0

摘要

目的:本研究的主要目的是研究普瑞巴林(PGB)如何影响纤维肌痛综合征(FMS)患者的促炎细胞因子释放。患者与方法:本实验研究纳入85名女性(平均年龄:49.6±10.1岁;从2020年4月到2020年11月。在参与者中,30名FMS患者使用PGB 150毫克/天至少三个月,30名FMS患者不使用PGB, 25名健康个体。FMS检测依据2010年美国风湿病学会诊断标准进行。采用酶联免疫吸附法检测促炎细胞因子(白细胞介素[IL]-2、IL-6、IL-12、IL-17、干扰素γ和肿瘤坏死因子α)的水平。结果:PGB可显著降低FMS患者血清促炎细胞因子浓度(PGB)。结论:PGB可抑制促炎细胞因子的释放,提示PGB可作为炎症病例的抗炎药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pregabalin inhibits proinflammatory cytokine release in patients with fibromyalgia syndrome.

Pregabalin inhibits proinflammatory cytokine release in patients with fibromyalgia syndrome.

Pregabalin inhibits proinflammatory cytokine release in patients with fibromyalgia syndrome.

Pregabalin inhibits proinflammatory cytokine release in patients with fibromyalgia syndrome.

Objectives: The main goal of the study was to investigate how pregabalin (PGB) affects proinflammatory cytokine release in patients with fibromyalgia syndrome (FMS).

Patients and methods: This experimental research study was conducted with 85 female participants (mean age: 49.6±10.1 years; range, 30 to 73 years) between April 2020 and November 2020. Of the participants, 30 were FMS patients using PGB 150 mg/day for at least three months, 30 were FMS patients not using PGB, and 25 were healthy individuals. The detection of FMS was carried out according to the 2010 American College of Rheumatology diagnostic criteria. Levels of proinflammatory cytokines (interleukin [IL]-2, IL-6, IL-12, IL-17, interferon-gamma, and tumor necrosis factor-alpha) were measured by enzyme-linked immunosorbent assay.

Results: Serum concentrations of proinflammatory cytokines were remarkably decreased in FMS patients using PGB (p<0.001) and were higher in patients with FMS not using PGB than in healthy subjects (p<0.001). The highest values of proinflammatory cytokines were found in the group of FMS patients not using PGB (p<0.001).

Conclusion: These results indicate that PGB inhibits the release of proinflammatory cytokines, suggesting that it can be used as an anti-inflammatory agent in inflammatory cases.

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来源期刊
Archives of rheumatology
Archives of rheumatology Medicine-Rheumatology
CiteScore
2.00
自引率
9.10%
发文量
15
期刊介绍: The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).
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