酿酒酵母PROPPIN Atg18、Atg21和Hsv2的自噬和非自噬功能。

IF 2.9 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Chemistry Pub Date : 2023-05-05 Print Date: 2023-07-26 DOI:10.1515/hsz-2023-0126

Lisa Marquardt, Michael Thumm

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引用次数: 1

摘要

Atg18、Atg21和Hsv2是与PI3P和PI（3，5）P2结合的同源β-推进器蛋白。Atg18被认为在生长中的自噬体（吞噬体）与内质网和液泡的接触位点组织脂质转移蛋白复合物。Atg21仅限于液泡吞噬体接触，在那里它组织了Atg8脂质化机制的一部分。Hsv2的作用尚不清楚，它在一定程度上影响微核。Atg18进一步参与调节PI（3，5）P2的合成。最近，一种新的Atg18逆转录酶复合体及其在液泡稳态和膜分裂中的作用被发现。

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Autophagic and non-autophagic functions of the Saccharomyces cerevisiae PROPPINs Atg18, Atg21 and Hsv2.

Atg18, Atg21 and Hsv2 are homologous β-propeller proteins binding to PI3P and PI(3,5)P₂. Atg18 is thought to organize lipid transferring protein complexes at contact sites of the growing autophagosome (phagophore) with both the ER and the vacuole. Atg21 is restricted to the vacuole phagophore contact, where it organizes part of the Atg8-lipidation machinery. The role of Hsv2 is less understood, it partly affects micronucleophagy. Atg18 is further involved in regulation of PI(3,5)P₂ synthesis. Recently, a novel Atg18-retromer complex and its role in vacuole homeostasis and membrane fission was uncovered.

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来源期刊

Biological Chemistry 生物-生化与分子生物学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.